Results were reviewed and interpreted by all authors and all authors were involved in Results: Two applications were identified: telemedicine to facilitate video conferencing as an alternative to outpatient consultations and telehealth monitoring for patients with respiratory failure. One randomised controlled trial using telehealth in patients with respiratory failure including 22 patients with ALS was identified.Whilst rates of hospitalisation were reduced, overall mortality was unchanged and there were too few patients with ALS in the study to detect significant benefit.Conclusion: There is limited evidence to support use of telemedicine or telehealth in the care of patients with ALS. Future research needs to develop an understanding of the key beneficial aspects of the traditional specialist ALS service and how these factors could be delivered using technology. Successful evaluation and implementation of technologies to facilitate access to specialist care will only be possible if all the relevant impacts of an intervention are understood and measured.