Economic Electrochemical Sensors for the Determination of Eszopiclone in Pharmaceutical Formulation with Greenness Profile Assessment

Abstract

Electrochemical‐ion‐selective‐sensors offer green, rapid, economic and simple analytical‐tool in pharmaceutical industry, control processes, physiological measurements and environmental monitoring. In this study, two sensors were introduced for eszopiclone (EZP) determination in pure‐form and in pharmaceutical‐dosage‐forms using drug‐ion‐exchanger association complex fabrication technique. Two different ion‐exchangers were used and compared, tetrakis (4‐chlorophenyl) borate in sensor1 and tetraphenyl borate in sensor 2. Such sensors showed superior performance at pH 3.5 over a wide‐range of EZP concentration. The proposed method was also assessed using GAPI and analytical Eco‐scale. Low cost, short analysis‐time, simplicity and greenness of the proposed sensors allow their use for high‐through‐put analysis in quality‐control laboratories.

Potentiometric Sensor Arrays Based on Hybrid PFSA/CNTs Membranes for the Analysis of UV-Degraded Drugs

“…The potentiometric selective determination of active ingredients in pharmaceutical drugs is possible mainly due to the introduction of ion pairs of analytes into a poly (vinyl chloride) (PVC) membrane. Therefore, a sensor with an inner reference solution based on tetrakis (4-chlorophenyl) borate used as an ionophore was developed for the selective determination of eszopiclone [ 25 ]. The same cation exchanger along with 2-hydroxy propyl-β-cyclodextrin were introduced into the PVC membrane of solid contact potentiometric sensors for the determination cyclopentolate hydrochloride and phenylephrine hydrochloride in the presence of their alkali and oxidative degradation products, respectively [ 26 ].…”