Economic evaluation of duloxetine versus serotonin selective reuptake inhibitors and venlafaxine XR in treating major depressive disorder in Scotland☆

Benedict, Ágnes; Arellano, Jorge; Cock, E De; Baird, Jessamy

doi:10.1016/j.jad.2009.04.017

Cited by 27 publications

(34 citation statements)

References 29 publications

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“…304 A utility decrement for osteoarthritis was taken from a HTA, 305 and a utility decrement for depression was calculated from a trial that had used the EQ-5D. 306 The multiplicative utility factors that are used in the model to describe health utility decrements from comorbid complications are shown in Table 46. The mean absolute decrement estimated in each study is reported alongside the baseline utility for each study.…”

Section: Utility Decrementsmentioning

confidence: 99%

Screening for glucose intolerance and development of a lifestyle education programme for prevention of type 2 diabetes in a population with intellectual disabilities: the STOP Diabetes research project

Dunkley

Tyrer

Spong

et al. 2017

Programme Grants Appl Res

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BackgroundThe prevalence of type 2 diabetes mellitus (T2DM) and of cardiovascular disease (CVD) is believed to be higher among people with intellectual disability (ID) than in the general population. However, research on prevalence and prevention in this population is limited.ObjectivesThe objectives of this programme of work were to establish a programme of research that would significantly enhance the knowledge and understanding of impaired glucose regulation (IGR) and T2DM in people with ID; to test strategies for the early identification of IGR and T2DM in people with ID; and to develop a lifestyle education programme and educator training protocol to promote behaviour change in a population with ID and IGR (or at a high risk of T2DM/CVD).SettingLeicestershire, UK.ParticipantsAdults with ID were recruited from community settings, including residential homes and family homes. Adults with mild to moderate ID who had an elevated body mass index (BMI) of ≥ 25 kg/m2and/or IGR were invited to take part in the education programme.Main outcome measuresThe primary outcome of the screening programme was the prevalence of screen-detected T2DM and IGR. The uptake, feasibility and acceptability of the intervention were assessed.Data sourcesParticipants were recruited from general practices, specialist ID services and clinics, and through direct contact.ResultsA total of 930 people with ID were recruited to the screening programme: 58% were male, 80% were white and 68% were overweight or obese. The mean age of participants was 43.3 years (standard deviation 14.2 years). Bloods were obtained for 675 participants (73%). The prevalence of previously undiagnosed T2DM was 1.3% [95% confidence interval (CI) 0.5% to 2%] and of IGR was 5% (95% CI 4% to 7%). Abnormal IGR was more common in those of non-white ethnicity; those with a first-degree family history of diabetes; those with increasing weight, waist circumference, BMI, diastolic blood pressure or triglycerides; and those with lower high-density lipoprotein cholesterol. We developed a lifestyle educational programme for people with ID, informed by findings from qualitative stakeholder interviews (health-care professionals,n = 14; people with ID,n = 7) and evidence reviews. Subsequently, 11 people with ID (and carers) participated in pilot education sessions (two groups) and five people attended education for the feasibility stage (one group). We found that it was feasible to collect primary outcome measures on physical activity and sedentary behaviour using wrist-worn accelerometers. We found that the programme was relatively costly, meaning that large changes in activity or diet (or a reduction in programme costs) would be necessary for the programme to be cost-effective. We also developed a quality development process for assessing intervention fidelity.LimitationsWe were able to screen only around 30% of the population and involved only a small number in the piloting and feasibility work.ConclusionsThe results from this programme of work have significantly enhanced the existing knowledge and understanding of T2DM and IGR in people with ID. We have developed a lifestyle education programme and educator training protocol to promote behaviour change in this population.Future workFurther work is needed to evaluate the STOP Diabetes intervention to identify cost-effective strategies for its implementation.Trial registrationClinicalTrials.gov NCT02513277.FundingThe National Institute for Health Research Programme Grants for Applied Research programme and will be published in full inHealth Research Programme Grants for Applied Research; Vol. 5, No. 11. See the NIHR Journals Library website for further project information.

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Section: Utility Decrementsmentioning

confidence: 99%

Screening for glucose intolerance and development of a lifestyle education programme for prevention of type 2 diabetes in a population with intellectual disabilities: the STOP Diabetes research project

Dunkley

Tyrer

Spong

et al. 2017

Programme Grants Appl Res

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“…The four economic evaluations identified in the systematic literature review were carried out in various countries: Scotland, 86 Singapore, 87 Thailand 88 and the USA. 89 The study by Benedict et al 86 was from the perspective of the Scottish NHS.…”

Section: Overview Of Included Economic Evaluationsmentioning

confidence: 99%

“…89 The study by Benedict et al 86 was from the perspective of the Scottish NHS. Therefore, the costs and resources considered in the evaluation by Benedict et al 86 were the most relevant to the decision problem that is the focus of this review. However, it is well established that TRD is associated with a substantial societal burden.…”

Section: Overview Of Included Economic Evaluationsmentioning

confidence: 99%

“…However, it is well established that TRD is associated with a substantial societal burden. 16,22 Benedict et al 86 considered the impact of the societal perspective in sensitivity analysis. The US study by Simpson et al 89 took a similar approach to that of Benedict et al 86 (payer perspective as the base case and societal perspective in sensitivity analysis), whereas the studies carried out in Thailand 88 and Singapore 87 were conducted from a payer and societal perspective, respectively.…”

Section: Overview Of Included Economic Evaluationsmentioning

confidence: 99%

“…The full-text publication of 23 studies identified as potentially relevant by both reviewers (LN and NT) were ordered and independently assessed for inclusion, using the criteria outlined in Table 6. Following the full-text review, 19 studies were excluded and four economic evaluations [86][87][88][89] were identified for final inclusion ( Table 7). The study selection process is summarised in Figure 11.…”

mentioning

confidence: 99%

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Lithium or an atypical antipsychotic drug in the management of treatment-resistant depression: a systematic review and economic evaluation

Edwards¹,

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Nherera³

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Cost-effectiveness of Electroconvulsive Therapy vs Pharmacotherapy/Psychotherapy for Treatment-Resistant Depression in the United States

2018

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Economic evaluation of duloxetine versus serotonin selective reuptake inhibitors and venlafaxine XR in treating major depressive disorder in Scotland☆

Cited by 27 publications

References 29 publications

Screening for glucose intolerance and development of a lifestyle education programme for prevention of type 2 diabetes in a population with intellectual disabilities: the STOP Diabetes research project

Screening for glucose intolerance and development of a lifestyle education programme for prevention of type 2 diabetes in a population with intellectual disabilities: the STOP Diabetes research project

Lithium or an atypical antipsychotic drug in the management of treatment-resistant depression: a systematic review and economic evaluation

Cost-effectiveness of Electroconvulsive Therapy vs Pharmacotherapy/Psychotherapy for Treatment-Resistant Depression in the United States

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