“…Only four research articles on MNs economic evaluation have been accessed to date, and all of them have focused on vaccination application. [194][195][196][197] The following evaluation aspects can provide a cost-benefit overview to the developers and help in decisions making which rational option to go forward and which to forgo. For instance, the cost analysis involving direct costs (manufacturing, inventory, raw materials, manufacturing expenses), indirect costs (electricity, management overhead costs, rent, utilities), intangible costs (impact on customers, employees, or delivery times), opportunity costs (investments equipment), and potential risk-related costs such as regulatory, competition, and environmental is extremely beneficial.…”