Economic evaluation of therapeutic interventions to prevent Type 2 diabetes in Canada

J., J.; Getsios, Denis; Caro, Ingrid; Klittich, Wendy S.; O’Brien, Judith A.

doi:10.1111/j.1464-5491.2004.01330.x

Cited by 61 publications

(105 citation statements)

References 29 publications

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“…Caro and colleagues 173 predicted from their model that over the 10-year period considered, 70 of the 1000 IGT patients in the cohort would be expected to die in the absence of treatment and 543 would develop diabetes. Intensive lifestyle modification was estimated to prevent 117 of these cases and metformin and acarbose were estimated to prevent 52 and 74 cases, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…Palmer and colleagues 172 used a similar approach to Caro and colleagues 173 to extrapolate the findings from the DPP trial over the lifetime of patients. They assessed the long-term costs and outcomes of the lifestyle and metformin interventions, as reported in the DPP trial, 90 relative to the control arm.…”

Section: Statement Of Decision Problemmentioning

confidence: 99%

“…174 There is also a lack of transparency in the reporting of the model by Caro and colleagues. 173 In this model, some of the assumptions used to model life expectancy and LYGs were unclear and not explicitly justified. In the model by McEwan and colleagues, 175 it was not possible to ascertain the methods used to model the microvascular complications.…”

Section: Conclusion Of the Critical Appraisalsmentioning

confidence: 99%

“…Hence the cohort modelled by Palmer and colleagues is substantially different from that modelled by Caro and colleagues. 173 Herman and associates 171 also conducted their analysis for a cohort based on the characteristics of patients enrolled in the DPP trial. The demographic characteristics and modifiable risk factors of the cohort modelled by McEwan and colleagues 175 were not reported in the available poster but the model cohort consisted of 1000 patients.…”

Section: Cohort Informationmentioning

confidence: 99%

“…Caro and colleagues 173 conducted their analysis for a cohort of 1000 patients with the characteristics of those enrolled in a recent randomised trial of interventions to prevent diabetes, the Study To Prevent Non-insulin Dependent Diabetes Mellitus (STOP-NIDDM). 169 Participants were predominantly Caucasians from Canada, Germany, Austria, Norway, Denmark, Sweden, Finland, Israel and Spain, with a mean age of 54.5 years and a BMI between 25 and 40 kg/m 2 .…”

Section: Cohort Informationmentioning

confidence: 99%

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Section: Resultsmentioning

confidence: 99%

Section: Statement Of Decision Problemmentioning

confidence: 99%