Economic evaluation of varicella vaccination in Spain—Results from a dynamic model

Lenne, X.; Díez-Domingo, Javier; Gil, Á.; Ridao, Manuel; Lluch, J.A.; Dervaux, B.

doi:10.1016/j.vaccine.2006.04.051

Cited by 40 publications

(51 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Chickenpox, a highly transmissible childhood disease that becomes more severe with age, has a 10-30 times greater mortality rate for adults than for juveniles [1,2]. Vaccination of children is currently recommended by the Centers for Disease Control (CDC) in the USA prior to the widespread availability of the vaccine in 1995, there were an estimated 4 million annual cases of chickenpox resulting in 11 000 hospitalizations and 100 deaths in the USA [3,4].…”

Section: Introductionmentioning

confidence: 99%

Epidemiological game-theory dynamics of chickenpox vaccination in the USA and Israel

Liu

Kochin

Tekle

et al. 2011

J. R. Soc. Interface.

View full text Add to dashboard Cite

The general consensus from epidemiological game-theory studies is that vaccination coverage driven by self-interest (Nash vaccination) is generally lower than group-optimal coverage (utilitarian vaccination). However, diseases that become more severe with age, such as chickenpox, pose an exception to this general consensus. An individual choice to be vaccinated against chickenpox has the potential to harm those not vaccinated by increasing the average age at infection and thus the severity of infection as well as those already vaccinated by increasing the probability of breakthrough infection. To investigate the effects of these externalities on the relationship between Nash and utilitarian vaccination coverages for chickenpox, we developed a game-theory epidemic model that we apply to the USA and Israel, which has different vaccination programmes, vaccination and treatment costs, as well as vaccination coverage levels. We find that the increase in chickenpox severity with age can reverse the typical relationship between utilitarian and Nash vaccination coverages in both the USA and Israel. Our model suggests that to obtain herd immunity of chickenpox vaccination, subsidies or external regulation should be used if vaccination costs are high. By contrast, for low vaccination costs, improving awareness of the vaccine and the potential cost of chickenpox infection is crucial.

show abstract

Section: Introductionmentioning

confidence: 99%

Epidemiological game-theory dynamics of chickenpox vaccination in the USA and Israel

Liu

Kochin

Tekle

et al. 2011

J. R. Soc. Interface.

View full text Add to dashboard Cite

show abstract

“…The majority of the studies (63%) adopted both perspectives (payer and society) 28,29,30,34,35,36,37,40,41,42,43,44,45,46,48,50,51,52 , one study included the patient's perspective 44 , and three did not conduct an analysis from society's perspective 25,26,41 .…”

Section: Results Of Literature Searchmentioning

confidence: 99%

“…Table 3 summarizes the various models' characteristics. Of all the studies reviewed, 10 used dynamic models 29,30,36,40,42,43,45,48,51,52 , 16 used static models 25,26,27,28,32,33,34,35,38,39,41,44,46,47,49,50 , and one study used a pseudodynamic model 37 . The latter model was considered pseudodynamic because it did not incorporate the indirect effects of vaccination on the entire population, but appears to have applied reduced forces of infection to susceptible individuals in the vaccinated cohorts 2 .…”

Section: Results Of Literature Searchmentioning

confidence: 99%

“…Most of the dynamic models 29,36,42,45,51,52 were based on the initial dynamic model developed by Halloran et al 54 , and the others 30,40,43,48 were based on similar approaches. All the dynamic models included the indirect effects of vaccination on non-vaccinated individuals (herd immunity) in the analysis.…”

Section: Results Of Literature Searchmentioning

confidence: 99%

“…Some studies reported additional factors, such as vaccine coverage 29,34,35,36,45,51,52 , discount rate 25,28,29,37,40,41,42,43,46,52 , health benefits discount 42 , time horizon 43 , and second dose of vaccine 27,30 .…”

Section: Results Of Literature Searchmentioning

confidence: 99%

See 2 more Smart Citations

Impact of methodology on the results of economic evaluations of varicella vaccination programs: is it important for decision-making?

2009

View full text Add to dashboard Cite

show abstract

Cost‐Effectiveness Analysis, Health‐Care Policy, and Operations Research Models

Zaric

2011

Wiley Encyclopedia of Operations Research and Management Science

View full text Add to dashboard Cite

Cost‐effectiveness analysis is often used to formally investigate the trade‐offs between the economic costs and the health consequences of new medical technologies. Starting with Ontario and Australia in the early 1990s, many public sector drug plans began requiring cost‐effectiveness estimates for all new drugs prior to their approval for reimbursement. Owing to the difficulties in obtaining cost‐effectiveness estimates directly from clinical trials, many cost‐effectiveness estimates are obtained using decision‐analytic and Monte Carlo simulation models. In this article, we give a brief overview of cost‐effectiveness analysis in health care; we discuss some of the types of models that are commonly used and we give a description of how cost‐effectiveness analysis is used in health policy decision making in three different jurisdictions.

show abstract

Economic evaluation of varicella vaccination in Spain—Results from a dynamic model

Cited by 40 publications

References 45 publications

Epidemiological game-theory dynamics of chickenpox vaccination in the USA and Israel

Epidemiological game-theory dynamics of chickenpox vaccination in the USA and Israel

Impact of methodology on the results of economic evaluations of varicella vaccination programs: is it important for decision-making?

Cost‐Effectiveness Analysis, Health‐Care Policy, and Operations Research Models

Contact Info

Product

Resources

About