The study examines the impact of FDI and trade openness on income inequality in the ASEAN region through instrumental variables and two-stage least squares for panel-data models. The study is based on panel data from Word Bank, SWIID and UNCTAD of 9 ASEAN countries from 1990 to 2020. The model includes six macro control variables: financial development, GDP per capita, education, control of corruption, inflation and unemployment. The result shows FDI has a positive relationship with income inequality. Meanwhile, the group of variables of trade openness has various impacts on income inequality, such as the variable international trade in goods and imports from middle- and low-income countries have the opposite effect. In contrast, the variable exports to low- and middle-income countries and imports from high-income countries have a positive effect on the dependent variable, especially the variable exports to high-income countries are not statistically significant. The variables education, financial development, GDP per capita and inflation have negative effects on inequality, and unemployment and corruption control variables are not significant due to the individual characteristics of the sample. From there, policy implications that reduce income inequality through FDI, trade openness and other factors in the region are suggested.