Economic impact of pneumococcal conjugate vaccination in Brazil, Chile, and Uruguay

Abstract

Objectives. To evaluate the economic impact of vaccination with the pneumococcal 7-valent conjugate vaccine (PCV7) in

Epidemiology of acute otitis media in children of Latin America and the Caribbean: A systematic review and meta-analysis

“…The projected annual burden of disease using cumulative 5-year incidence in LA&C showed 10.5 million AOM cases for the region for a birth cohort of 11.7 million, resulting in a similar cumulative incidence percentage (89%), with 12% estimated to be caused by pneumococcus [47]. Total events of pneumococcal otitis media have been projected to be 108 events per 1000 children in Brazil, Chile and Uruguay (projected for the 2005 birth cohort during the first five years of life) [48]. Compared to this conservative assumption for this region, the reported incidence was 80-fold lower in Arevalo Silva et al [18] (incidence 1.1%), 2.5-fold lower in Nandi-Lozano et al [28] (incidence 36.0%), while intermediate values were observed in Gutierrez Trujillo et al [31] (incidence 4.5%) and Lopez 1998 (incidence 2.7%) [27].…”

Cost-effectiveness of introducing the 10-valent pneumococcal conjugate vaccine into the universal immunisation of infants in Brazil

“…The purpose of this study was to evaluate the cost-effectiveness of including the PCV10 into the routine childhood immunisation in Brazil. Previous studies evaluated the cost-effectiveness of an immunisation programme with PCV7 in Brazil, and their results suggested that this programme would be a very cost-effective intervention 4 5. To our knowledge this is the first study assessing the cost-effectiveness of an immunisation programme with PCV10, the vaccine introduced in the Brazilian NIP.…”

Epidemiology of Pediatric Pneumococcal Meningitis and Bacteremia in Latin America and the Caribbean

“…The most frequent serotype isolated in children with meningitis in the region was serotype 14 in 28.5% of the samples (95% 44 Chile, 29,48 Uruguay 29,48,58 and the LAC region globally. 50 The pooled mean length of stay per pneumococcal meningitis case was 15 days (95% CI: 12.6-17.5).…”