Economic impact of the reduced incidence of atrial fibrillation in patients with heart failure treated with enalapril

Wagner, Monika; Rindress, Donna; Desjardins, Brigitte; Meilleur, Marie-Claude; Ducharme, Anique; Tardif, Jean‐Claude

doi:10.1016/j.ahj.2005.07.027

“…Because of accelerated NH activation, SDB may exacerbate pulmonary and cardiovascular conditions, leading to shorter lifespans, specifically if the SDB is untreated. Angiotensin‐converting enzyme (ACE) inhibitors have been shown to reduce the incidence of atrial fibrillation, an arrhythmia associated with cerebrovascular events, lending support for NH sequelae in brain pathology and cognitive functioning 31 . In addition, research has shown that sleep disturbances impair quality of life and overall functional performance, including cognitive abilities 32 .…”

Section: Nh Activation In Sdbmentioning

confidence: 99%

“…SDB is also linked to an increased incidence of cerebrovascular disease, such as stroke or transient ischemia attacks, both known to negatively impact cognitive abilities. While little evidence is available on interventions to improve cognitive functioning in sleep‐deprived individuals, high‐dose ACE inhibition has been suggested as treatment to block the NH effects seen with sleep deprivation 31 …”

Section: Cognitive Functioningmentioning

confidence: 99%

Sleep‐Disordered Breathing, Cognitive Functioning, and Adherence in Heart Failure: Linked Through Pathology?

Trupp

¹

,

Corwin

²

2008

Progress Cardiovascular Nurs

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Heart failure (HF) is well recognized as a condition resulting from chronic neurohormonal activation. Sleep-disordered breathing (SDB) as a neurohormonal disorder is less recognized. In SDB, whether obstructive or central in nature, nightly repetitive cycles of hypoxia-reoxygenation produce intense sympathetic activation and deprive the body of much needed sleep. Both HF and SDB are associated with fatigue, cognitive impairment, and challenges for adherence to prescribed therapies. Together, the combination of HF and SDB can have particularly ominous consequences for cognitive functioning, decision making, adherence and, ultimately, outcomes. The suboptimal adherence seen in patients with both HF and SDB may result from a neurohormonal synergism that exists between the 2 conditions.

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Association of pretreatment with angiotensin-converting enzyme inhibitors with improvement in ablation outcome in atrial fibrillation patients with low left ventricular ejection fraction

Mohanty

¹

,

Mohanty

²

,

Trivedi

³

et al. 2015

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Sleep-Disordered Breathing, Cognitive Functioning, and Adherence in Heart Failure: Linked Through Pathology?

Trupp

¹

,

Corwin

²

2008

Progress in Cardiovascular Nursing

View full text Add to dashboard Cite

Heart failure (HF) is well recognized as a condition resulting from chronic neurohormonal activation. Sleep-disordered breathing (SDB) as a neurohormonal disorder is less recognized. In SDB, whether obstructive or central in nature, nightly repetitive cycles of hypoxia-reoxygenation produce intense sympathetic activation and deprive the body of much needed sleep. Both HF and SDB are associated with fatigue, cognitive impairment, and challenges for adherence to prescribed therapies. Together, the combination of HF and SDB can have particularly ominous consequences for cognitive functioning, decision making, adherence and, ultimately, outcomes. The suboptimal adherence seen in patients with both HF and SDB may result from a neurohormonal synergism that exists between the 2 conditions. Prog Cardiovasc Nurs. 2008;23;32-36.

show abstract

Economic impact of the reduced incidence of atrial fibrillation in patients with heart failure treated with enalapril

Cited by 3 publications

References 43 publications

Sleep‐Disordered Breathing, Cognitive Functioning, and Adherence in Heart Failure: Linked Through Pathology?

Sleep‐Disordered Breathing, Cognitive Functioning, and Adherence in Heart Failure: Linked Through Pathology?

Association of pretreatment with angiotensin-converting enzyme inhibitors with improvement in ablation outcome in atrial fibrillation patients with low left ventricular ejection fraction

Sleep-Disordered Breathing, Cognitive Functioning, and Adherence in Heart Failure: Linked Through Pathology?

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