With the increasing power load, the power supply pressure of the distribution network increases, among which the impact load has the characteristics of large instantaneous power and fast power growth, which makes the distribution network face problems such as insufficient capacity and short-term supply and demand imbalance. The load interlock method has been used in the past to cope with the impact load of the distribution network. Still, this method forcibly schedules the user load, affects the user’s power consumption experience, and makes it difficult to ensure sufficient dispatch. To solve this problem, this paper adopts a distribution network demand response scheduling based on impact load screening and prediction. By applying the outlier anomaly detection algorithm, the impact load is screened from numerous loads. Then, the required impact load is determined according to the maximum amount of allowable dispatch in the distribution network lines and the location of the grid load nodes. Then, a demand response resource scheduling model that considers shock load is established. This method solves the problem of insufficient capacity caused by shock load, avoids the cost caused by power network expansion, and gives economic compensation to users through demand response, achieving a win-win situation.