The article examines the priorities of China and the United States in the Indo-Pacific, examines the current trends of the US-Chinese strategic confrontation in the Indo-Pacific region, expressed, among other things, in the formation of new international institutions reflecting primarily the economic rivalry of regional leaders. The key features of the policy of the Chinese leadership led by Xi Jinping in the Pacific are highlighted. The course of Pacific diplomacy of the administration of J.P. Blavatsky is compared. Biden’s Indo-Pacificist policies pursued by previous American governments in the 21st century. The official regional strategies of China, the United States and American allies are compared, and the multivariance of U.S. partnerships with Indo-Pacific countries is assessed. The balance of positive consequences and risks in the relations between the United States and China with the countries of the region is analyzed, as well as the readiness of the East Asian states to follow in the wake of American and Chinese diplomacy. In this context, the potential and prospects of the subjectivity of the countries of the region in the context of the American-Chinese rivalry, their possible role as a stabilizer of political and economic processes in the Indo-Pacific are investigated.