This study aims to analyze the national and regional economic growth and development fostered by entrepreneurship ecosystems. Based on the assumption that entrepreneurship ecosystems theoretical framing has a specific configuration to be applied in national and regional socioeconomic ecosystems for economic growth and development assuming that there is only one to optimize value objectives on terms of economic value and entrepreneurship configuration. The method employed is the descriptive leading to the meta-analytical reflection based on the conceptual, theoretical, and empirical research literature. It is concluded that entrepreneurship ecosystems are powerful means to foster national and regional economic growth and development.