Economic strategies in the issue of controlling AIDS

Wang, Qixin; Liu, Yang; Zhang, Bodi

doi:10.1109/iccme.2007.4382011

Cited by 1 publication

(2 citation statements)

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“…When T-bet binds to the gene that can be transcribed and translated into IFN   , histone acetylation and DNA methylation are catalyzed and the gene is modified, hence the alteration of its accessibility, which leads to chromatin remodeling [18][19][20][21]. Generally, the IFN   gene undergoes morphological changes so that it can be transcribed more easily.…”

Section: Ifn mentioning

confidence: 99%

“…Afterwards, STAT-1 activates the transcription factor T-bet, which plays a dominant role in regulating the differentiation of T-helper cells (Chakir et al, 2003). When T-bet binds to the gene that can be transcribed and translated into IFN-gamma, histone acetylation and DNA methylation are catalyzed and the gene is modified, hence the alteration of its accessibility, which leads to chromatin remodeling (Robinson and Lloyd, 2002;Lovett-Racke et al, 2004;Mariani et al, 2004;Wang et al, 2007b). Generally, the IFN-gamma gene undergoes morphological changes so that it can be transcribed more easily.…”

Section: Introductionmentioning

confidence: 99%

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Genetic analysis of differentiation of T-helper lymphocytes

Wang¹,

Li²,

Li³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. In the human immune system, T-helper cells are able to differentiate into two lymphocyte subsets: Th1 and Th2. The intracellular signaling pathways of differentiation form a dynamic regulation network by secreting distinctive types of cytokines, while differentiation is regulated by two major gene loci: T-bet and GATA-3. We developed a system dynamics model to simulate the differentiation and re-differentiation process of T-helper cells, based on gene expression levels of T-bet and GATA-3 during differentiation of these cells. We arrived at three ultimate states of the model and came to the conclusion that cell differentiation potential exists as long as the system dynamics is at an unstable equilibrium point; the T-helper cells will no Genetic analysis of Th cell differentiation longer have the potential of differentiation when the model reaches a stable equilibrium point. In addition, the time lag caused by expression of transcription factors can lead to oscillations in the secretion of cytokines during differentiation.

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Section: Ifn mentioning

confidence: 99%