“…It is likely that such scenarios do not match with optimal solutions, especially in complex systems (Ekvall et al., 2007). Since 1998 (Azapagic & Clift, 1998, 1999), LCA and input–output (IO) practitioners have used an optimization approach for a broad range of applications, such as waste management (Kondo & Nakamura, 2005), energy (Saner et al., 2014), transport (Hung et al., 2022), biofuels (Wietschel et al., 2021), biorefinery technologies (Budzinski et al., 2019), and many others. The method has demonstrated its ability to quickly, explicitly, efficiently, and autonomously provide the optimal technological combination by exploring the whole solution space.…”