Ecotoxic effects of the vehicle solvent dimethyl sulfoxide on Raphidocelis subcapitata, Daphnia magna and Brachionus calyciflorus

Andrade-Vieira, Larissa Fonseca; Bojic, Clément; Alvarenga, Ingrid Fernanda Santana; Carvalho, Teotônio Soares de; Masfaraud, Jean-François; Cotelle, Sylvie

doi:10.1080/02757540.2022.2076838

Cited by 3 publications

(2 citation statements)

References 22 publications

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“…When a solvent is used in toxicity testing as a vehicle for poorly water solubilizing chemicals, its potential influence on the test results must be considered. Here, DMSO was used because it has been recommended as the first choice for an organic solvent due to its low toxicity to D. magna (48 h immobilization LC 50 = 1.2% [37]; 25-day reproduction NOEC = 0.1% [38]) compared to other widely used organic solvents [39]. In the toxicity tests where D. magna was exposed to 0.002% (v/v) DMSO, we observed a stimulation of ephippia hatching, reproduction at F0 and in the lipid content of adults.…”

Section: Discussionmentioning

confidence: 99%

“…However, the increased parental lipid content was accompanied by increased reproduction only in F0 when exposed to 1 mg 1-HCHPK/L and DMSO (Figure 1). Further, in the life-cycle analysis, the DMSO concentrations were 5-fold lower than recommended for toxicity testing [43] OECD, 2019), and were demonstrated to be safe for D. magna and its food source, R. subcapitata (≤0.01%, v/v) [37]. We hypothesize that the stimulatory effects on the ephippia hatching and parental lipid content we observed in the life-cycle experiment (Figure 1) are (at least partially) attributable to the DMSO.…”

Section: Discussionmentioning

confidence: 99%

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Toxicity of Plastic Additive 1-Hydroxycyclohexyl Phenyl Ketone (1-HCHPK) to Freshwater Microcrustaceans in Natural Water

Blinova,

Lukjanova,

Vija

et al. 2023

Water

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Various potentially toxic compounds associated with plastic (e.g., plastic additives) can enter the environment during plastic fragmentation and/or weathering. 1-Hydroxycyclohexyl phenyl ketone (1-HCHPK) is a widely used photoinitiator, e.g., in UV-radiation-curable technologies such as 3D-printing, plastic coatings and construction materials. 1-HCHPK may reach aquatic ecosystems via various waste-flows, including leaching from consumer goods. However, knowledge of its potential environmental hazard is scarce. In the present study, we addressed this data gap by assessing the acute and long-term toxicity of 1-HCHPK to freshwater microcrustaceans in environmentally relevant conditions using natural waters. The results showed that the acute toxicity of 1-HCHPK (L(E)C50) to pelagic Thamnocephalus platyurus and Daphnia magna and benthic Heterocypris incongruens ranged between 27 and 55 mg/L. Further, the long-term exposure of D. magna to low levels of 1-HCHPK (0.1 and 1.0 mg/L) did not affect ephippia hatching or organismal fitness, even in three successive daphnid generations. Thus, 1-HCHPK did not pose a hazard to the freshwater microcrustaceans at concentrations < 1 mg/L in the environmentally relevant conditions (i.e., multigenerational life cycle tests conducted in lake water at low chemical exposure concentrations). The tests employed in this study allowed for the environmentally relevant hazard assessment of emerging pollutants such as a plastic additive 1-HCHPK.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Toxicity of Plastic Additive 1-Hydroxycyclohexyl Phenyl Ketone (1-HCHPK) to Freshwater Microcrustaceans in Natural Water

Blinova,

Lukjanova,

Vija

et al. 2023

Water

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Transgenerational Effects of Atrazine on Daphnia magna Based on Life-History Traits and Population Dynamics

Wang,

Li,

et al. 2024

Bull Environ Contam Toxicol

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Antibacterial Profiling of Zanthoxylum armatum Extracts: A Comprehensive Computational and Experimental Study

Mukhtar,

Khan,

Naz

2024

Natural Product Communications

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Objectives The current study was conducted to evaluate the antibacterial potential of leaf and fruit extracts of Zanthoxylum armatum against two pathogenic bacterial isolates, Staphylococcus aureus and Staphylococcus epidermidis. Methods Twelve commercially available antibiotics were tested S. aureus and S. epidermidis by antimicrobial susceptibility test (AST). Qualitative analysis of phytochemicals was performed to evaluate the presence of certain secondary metabolites. The activity of Z. armatum extracts against S. aureus and S. epidermidis was measured as a maximum zone of inhibition exhibited by each leaf and fruit extract. An in-silico study was conducted on flavonoids and alkaloids to show their binding affinity with the PBP2a receptor protein of S. aureus and TcaR of S. epidermidis. Results The AST revealed that S. aureus was resistant to Penicillin, Ampicillin, Clindamycin, Vancomycin, Rifampicin, Novobiocin, and Oxacillin, whereas S. epidermidis was resistant to Streptomycin, Oxacillin, Tetracycline, and Novobiocin. Qualitative analysis of phytochemicals resulted in the presence of Saponins, fixed oils, flavonoids, alkaloids, starch, and fatty acids in both leaf and fruit extracts. The maximum zone of inhibition against S. aureus was produced by methanolic leaf extracts of Z. armatum and chloroform fruit extracts. For S. epidermidis, the best activity was exhibited by benzene leaf extracts and methanolic fruit extracts. An in-silico study showed that flavonoids Nitidine and Nevadensin exhibited binding affinity with the PBP2a receptor protein higher than selected antibiotics, ie, Penicillin, Chloramphenicol, and Oxacillin. TcaR of S. epidermidis interacted with Tambuletin, followed by Nitidine and Kaempferol. Conclusion After in vitro testing, in silico analysis advised extracting and purifying the bioactive components from Z. armatum extracts that showed significant interaction with bacterial virulence proteins for use as natural antibiotics against antibiotic-resistant bacteria.

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Ecotoxic effects of the vehicle solvent dimethyl sulfoxide on Raphidocelis subcapitata, Daphnia magna and Brachionus calyciflorus

Cited by 3 publications

References 22 publications

Toxicity of Plastic Additive 1-Hydroxycyclohexyl Phenyl Ketone (1-HCHPK) to Freshwater Microcrustaceans in Natural Water

Toxicity of Plastic Additive 1-Hydroxycyclohexyl Phenyl Ketone (1-HCHPK) to Freshwater Microcrustaceans in Natural Water

Transgenerational Effects of Atrazine on Daphnia magna Based on Life-History Traits and Population Dynamics

Antibacterial Profiling of Zanthoxylum armatum Extracts: A Comprehensive Computational and Experimental Study

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