Ecotoxicity evaluation of tetramethrin and analysis in agrochemical formulations using chiral electrokinetic chromatography

Greño, Maider; Amariei, Georgiana; Boltes, Karina; Castro-Puyana, María; García, María Ángeles; Marina, Marı́a Luisa

doi:10.1016/j.scitotenv.2021.149496

Cited by 7 publications

(10 citation statements)

References 28 publications

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“…In addition, the treatment of a liquid sample by on-line electrokinetic preconcentration was also described [ 61 ]. Regarding agrochemical formulations, a direct dilution in H 2 O [ 19 , 52 ], MeOH [ 43 , 46 , 47 , 62 , 63 , 64 ], in a separation buffer containing urea and sodium deoxycholate (SDC) [ 20 ], or in the background electrolyte (BGE)/H 2 O (50:50, v / v ) [ 64 ] was carried out. The characteristics and applications of the methodologies developed for the chiral analysis of the compounds considered in this review are described in more detail as follows.…”

Section: Chiral Analysis Of Pesticides and Emerging Contaminants By Cementioning

confidence: 99%

“…On the other hand, tetramethrin is found in a 80:20 proportion of trans:cis isomers, respectively, with the 1R enantiomer of the trans isomer being more active than the other isomers, followed by the 1S-cis isomer [ 70 ]. This pyrethroid was stereoselectively separated by CE using a dual system of chiral selectors formed by SDC and HP-β-CD in a borate buffer at a pH of 8.0 [ 20 ]. The baseline separation of the four stereoisomers was obtained in less than 12.5 min.…”

Section: Chiral Analysis Of Pesticides and Emerging Contaminants By Cementioning

confidence: 99%

“…The CE separation modes employed in these cases were CD-EKC and CD-MEKC. The latter mode was selected as the separation mode in one of these works due to the low solubility of the compound using a mixture of the bile salt SDC and a neutral CD (HP-β-CD) [ 20 ]. CD-EKC with anionic CDs (Succ-β-CD, S-β-CD, S-γ-CD, and carboxyethyl-β-cyclodextrin (CE-β-CD)) was chosen in the other works, which are reported as shown in Table 2 .…”

Section: Applications Of Chiral Ce To Toxicity Studiesmentioning

confidence: 99%

“…Moreover, in general, toxicity parameters are calculated using initial concentrations of the pollutants and not their real concentrations in exposure tests. Several studies have recently been carried out to evaluate the stability and toxicity of the enantiomers of emerging chiral pollutants using their real concentrations as determined by CE [ 2 , 16 , 18 , 19 , 20 , 21 ]. In this sense, analytical separation techniques enable us to determine the concentration of stereoisomers in environmental samples and therefore to evaluate their individual stability and toxicity towards non-target organisms.…”

Section: Introductionmentioning

confidence: 99%

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Chiral Analysis of Pesticides and Emerging Contaminants by Capillary Electrophoresis—Application to Toxicity Evaluation

García-Cansino,

Marina,

García

2024

Toxics

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Chiral analysis is a very relevant topic in environmental chemistry. This is due to the different properties of the stereoisomers of chiral compounds. In the case of agrochemicals, the desired activity, degradation rate, or toxicity, among other characteristics, may differ between stereoisomers, and the same is true for emerging contaminants, such as pharmaceuticals and cosmetics. Therefore, the development of chiral analytical methodologies enabling their determination in samples of environmental interest is paramount. Although other techniques have been widely employed to carry out chiral separations, such as HPLC, GC, and SFC, capillary electrophoresis (CE) has attracted a lot of attention in the field of chiral analysis due to its simplicity, flexibility, and low cost. In fact, chromatographic columns are not needed, and the consumption of reagents and samples is very low due to the small dimensions of the separation capillaries. This article reviews the characteristics of the chiral methodologies developed by CE for the stereoselective analysis of pesticides and emerging contaminants in environmental samples (water and soil), as well as pesticides in food samples and commercial agrochemical formulations. Applications of the developed CE methodologies in stability and toxicity studies of these chiral contaminants are also reviewed.

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Section: Chiral Analysis Of Pesticides and Emerging Contaminants By Cementioning

confidence: 99%

Section: Chiral Analysis Of Pesticides and Emerging Contaminants By Cementioning

confidence: 99%

Section: Applications Of Chiral Ce To Toxicity Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Chiral Analysis of Pesticides and Emerging Contaminants by Capillary Electrophoresis—Application to Toxicity Evaluation

García-Cansino,

Marina,

García

2024

Toxics

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“…Tetramethrin (Figure A) is a highly effective type I pyrethroid insecticide for the defense of insects and mosquito in agricultural, gardening, or household application . The compound was synthesized and introduced as a racemate in 1965 by Sumitomo Chemical Company .…”

Section: Introductionmentioning

confidence: 99%

Systematic Stereoselectivity Evaluations of Tetramethrin Enantiomers: Stereoselective Cytotoxicity, Metabolism, and Environmental Fate in Earthworms, Soils, Vegetables, and Fruits

Wang²,

Guo³

et al. 2022

J. Agric. Food Chem.

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Tetramethrin is a widely applied type I chiral pyrethroid insecticide that exists as a mixture of four isomers. In the present study, its stereoselective cytotoxicity, bioaccumulation, degradation, and metabolism were investigated for the first time at the enantiomeric level in detail by using a sensitive chiral high-performance liquid chromatography−tandem mass spectroscopy (HPLC-MS/MS) method. Results showed that among rac-tetramethrin and its four enantiomers, the trans (+)-1R,3R-tetramethrin had the strongest inhibition effect on the PC12 cells. In the earthworm exposure trial, the concentration of trans (−)-1S,3Stetramethrin was 0.94−8.92 times in earthworms (cultivated in natural soil) and 1.67−5.01 times (cultivated in artificial soil) higher than trans (+)-1R,3R-tetramethrin, respectively. In the greenhouse experiment, the trans (+)-1R,3R-tetramethrin and cis (+)-1R,3Stetramethrin were preferentially degraded. Furthermore, for rat liver microsome in vitro incubation, the maximum metabolism rate of cis (−)-1S,3R-tetramethrin was 1.50 times higher than its antipodes. Altogether, the aim of this study was to provide a scientific and reasonable reference for the possibility of developing a single enantiomer to replace the application of rac-tetramethrin, which could possess better bioactivity and lower ecotoxicity, and thus permit more reliable and accurate environmental monitoring and risk assessment.

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Recent Advances on Chiral Mobile Phase Additives: A Critical Review

Jin

Cheng

et al. 2022

J. Anal. Test.

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Ecotoxicity evaluation of tetramethrin and analysis in agrochemical formulations using chiral electrokinetic chromatography

Cited by 7 publications

References 28 publications

Chiral Analysis of Pesticides and Emerging Contaminants by Capillary Electrophoresis—Application to Toxicity Evaluation

Chiral Analysis of Pesticides and Emerging Contaminants by Capillary Electrophoresis—Application to Toxicity Evaluation

Systematic Stereoselectivity Evaluations of Tetramethrin Enantiomers: Stereoselective Cytotoxicity, Metabolism, and Environmental Fate in Earthworms, Soils, Vegetables, and Fruits

Recent Advances on Chiral Mobile Phase Additives: A Critical Review

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