Ecotoxicity of chrysene and phenanthrene on meiobenthic nematodes with a case study of Terschellingia longicaudata: Taxonomics, toxicokinetics, and molecular interactions modelling

Are iron ore microparticles toxic for the European clam Ruditapes decussatus? Response elements from biomarker activities and in silico modeling

“…The negative impact on the health of clams, as reported by disruption in the assessed biomarkers, MDA levels, and decreased AChE activity might be the consequence of the bioavailability and toxicokinetic properties of iron ore. Such results might include interactions with the cytochrome P450 (Cyp) isoforms such as Cyp1A2, Cyp3A4, and CypC19… ( Ishak et al, 2022 , Badraoui et al, 2023 ). Interactions with Cyp are commonly assessed in toxicological approaches ( Badraoui et al, 2023 , Hedfi et al, 2022 ) as they are usually associated with mild to severe toxicological outcomes ( Allouche et al, 2022 , Hedfi et al, 2022 ).…”

“…Such results might include interactions with the cytochrome P450 (Cyp) isoforms such as Cyp1A2, Cyp3A4, and CypC19… ( Ishak et al, 2022 , Badraoui et al, 2023 ). Interactions with Cyp are commonly assessed in toxicological approaches ( Badraoui et al, 2023 , Hedfi et al, 2022 ) as they are usually associated with mild to severe toxicological outcomes ( Allouche et al, 2022 , Hedfi et al, 2022 ).…”

“…Bioavailability and toxicokinetic properties were investigated computationally, based on the physicochemical factors of hematite- and magnetite ore as reported earlier ( Badraoui et al, 2023; Jedli et al, 2022 , Zammel et al, 2022 ).…”