Ecotoxicological assessment of commercial boron nitride nanotubes toward <i>Xenopus laevis</i> tadpoles and host-associated gut microbiota

Evariste, Lauris; Flahaut, Emmanuel; Baratange, Clément; Barret, Maialen; Mouchet, Florence; Pinelli, Éric; Galibert, Anne Marie; Soula, Brigitte; Gauthier, Laury

doi:10.1080/17435390.2020.1839137

Cited by 19 publications

(4 citation statements)

References 115 publications

(118 reference statements)

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“…Apples, coffee, dry beans, milk, and potatoes are the five most prevalent sources of boron in a person’s daily diet. Boron intakes of 1–3 mg/day have been shown to improve bone and brain health in adults when compared to intakes of 0.25–0.50 mg/day [ 173 ]. The right amount of boron can help to create the intestinal organizational structure, which improves gastrointestinal absorption [ 173 ].…”

Section: Boron As a Neuroprotective Agentmentioning

confidence: 99%

The Role of Microbiome in Brain Development and Neurodegenerative Diseases

Nandwana

Das

et al. 2022

Molecules

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Hundreds of billions of commensal microorganisms live in and on our bodies, most of which colonize the gut shortly after birth and stay there for the rest of our lives. In animal models, bidirectional communications between the central nervous system and gut microbiota (Gut–Brain Axis) have been extensively studied, and it is clear that changes in microbiota composition play a vital role in the pathogenesis of various neurodevelopmental and neurodegenerative disorders, such as Autism Spectrum Disorder, Alzheimer’s disease, Parkinson’s disease, Multiple Sclerosis, Amyotrophic Lateral Sclerosis, anxiety, stress, and so on. The makeup of the microbiome is impacted by a variety of factors, such as genetics, health status, method of delivery, environment, nutrition, and exercise, and the present understanding of the role of gut microbiota and its metabolites in the preservation of brain functioning and the development of the aforementioned neurological illnesses is summarized in this review article. Furthermore, we discuss current breakthroughs in the use of probiotics, prebiotics, and synbiotics to address neurological illnesses. Moreover, we also discussed the role of boron-based diet in memory, boron and microbiome relation, boron as anti-inflammatory agents, and boron in neurodegenerative diseases. In addition, in the coming years, boron reagents will play a significant role to improve dysbiosis and will open new areas for researchers.

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Section: Boron As a Neuroprotective Agentmentioning

confidence: 99%

The Role of Microbiome in Brain Development and Neurodegenerative Diseases

Nandwana

Das

et al. 2022

Molecules

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“…To date, very few studies focused on other 2D materials such as MoS 2 , WS 2 , or hBN. However, it has been reported that free boron present in tested boron-containing nanomaterials is beneficial for Xenopus tadpole metabolism …”

Section: D Materials Impact On Vertebratesmentioning

confidence: 99%

Environmental and Health Impacts of Graphene and Other Two-Dimensional Materials: A Graphene Flagship Perspective

Lin,

Buerki-Thurnherr,

Kaur

et al. 2024

ACS Nano

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Two-dimensional (2D) materials have attracted tremendous interest ever since the isolation of atomically thin sheets of graphene in 2004 due to the specific and versatile properties of these materials. However, the increasing production and use of 2D materials necessitate a thorough evaluation of the potential impact on human health and the environment. Furthermore, harmonized test protocols are needed with which to assess the safety of 2D materials. The Graphene Flagship project (2013−2023), funded by the European Commission, addressed the identification of the possible hazard of graphene-based materials as well as emerging 2D materials including transition metal dichalcogenides, hexagonal boron nitride, and others. Additionally, socalled green chemistry approaches were explored to achieve the goal of a safe and sustainable production and use of this fascinating family of nanomaterials. The present review provides a compact survey of the findings and the lessons learned in the Graphene Flagship.

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“…Thus, butyrate increases iodine uptake and the expression of thyroid hormone receptors in mice [200,201]. Regarding the nutritional intake of B, the most important research studies regarding the supplementation of the diet with B in animals and humans have shown the following: (a) healthy women fed with a diet rich in B (10 mg B per day) have a significant decrease of 25% in the thyroid-stimulating hormone (TSH, thyrotropin) level [202]; (b) B shows an iodine-like effect while investigating the influence on tail maturation of Xenopus laevis frogs, i.e., tail maturation in X. laevis is modulated by the thyroid axis [203,204]; (c) dietary supplementation with BA (400 mg/kg) during a 4-month period increased the level of triiodothyronine (T3) of the rams in the serum samples compared with control [205]. There were also some contradictory results, but in general, favorable effects were observed with the B diet in animals and humans [206].…”

Section: Microbiota-gut-immune Systemmentioning

confidence: 99%

Microbiota-Accessible Boron-Containing Compounds in Complex Regional Pain Syndrome

Biţă,

Scorei,

Vreju

et al. 2023

Medicina

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The microbiota–gut–brain axis has garnered increasing attention in recent years for its role in various health conditions, including neuroinflammatory disorders like complex regional pain syndrome (CRPS). CRPS is a debilitating condition characterized by chronic neuropathic pain, and its etiology and pathophysiology remain elusive. Emerging research suggests that alterations in the gut microbiota composition and function could play a significant role in CRPS development and progression. Our paper explores the implications of microbiota in CRPS and the potential therapeutic role of boron (B). Studies have demonstrated that individuals with CRPS often exhibit dysbiosis, with imbalances in beneficial and pathogenic gut bacteria. Dysbiosis can lead to increased gut permeability and systemic inflammation, contributing to the chronic pain experienced in CRPS. B, an essential trace element, has shown promise in modulating the gut microbiome positively and exerting anti-inflammatory effects. Recent preclinical and clinical studies suggest that B supplementation may alleviate neuropathic pain and improve CRPS symptoms by restoring microbiota balance and reducing inflammation. Our review highlights the complex interplay between microbiota, inflammation, and neuropathic pain in CRPS and underscores the potential of B as a novel therapeutic approach to target the microbiota–gut–brain axis, offering hope for improved management of this challenging condition.

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Ecotoxicological assessment of commercial boron nitride nanotubes toward Xenopus laevis tadpoles and host-associated gut microbiota

Abstract: assessment of commercial boron nitride nanotubes toward Xenopus laevis tadpoles and host-associated gut microbiota. (2021) Nanotoxicology, 15 (1). 35-51.

Cited by 19 publications

References 115 publications

The Role of Microbiome in Brain Development and Neurodegenerative Diseases

The Role of Microbiome in Brain Development and Neurodegenerative Diseases

Environmental and Health Impacts of Graphene and Other Two-Dimensional Materials: A Graphene Flagship Perspective

Microbiota-Accessible Boron-Containing Compounds in Complex Regional Pain Syndrome

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