Ecotoxicological assessment of the effects of fluoxetine on Daphnia magna based on acute toxicity, multigenerational reproduction effects, and attraction-repellence responses

Stremmel, Helmut; Weiss, Linda C.; Parra, Gema; Ramos–Rodríguez, Eloísa; Araújo, Cristiano V.M.

doi:10.1016/j.chemosphere.2022.137028

Cited by 7 publications

(2 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Numerous biological endpoints including growth and reproduction, oxidative stress response, and transcriptomic and metabolomic responses have been analyzed in studies investigating the effects of FLX in daphnid species (Flaherty and Dodson 2005 ; Campos et al 2012a , 2016 ; Jordão et al 2016 ; Ding et al 2017 ; Stremmel et al 2023 ). According to these studies, it is understood that FLX has a harmful potential on daphnid populations.…”

Section: Introductionmentioning

confidence: 99%

“…Exposure to FLX at concentrations of 40 and 80 µg/L has been associated with various documented biological consequences (Campos et al 2012a , 2016 ). According to Stremmel et al ( 2023 ), FLX concentrations in aquatic environments will eventually reach lethal concentrations (up to 800 µg/L) in the worst-case scenario for future projections; therefore, we selected higher concentrations than current environmental levels for this study.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Binary effects of fluoxetine and zinc on the biomarker responses of the non-target model organism Daphnia magna

Atli,

Sevgiler

2024

Environ Sci Pollut Res

View full text Add to dashboard Cite

The antidepressant effect of zinc on mammals has been documented in recent decades, and the concentration of the antidepressant fluoxetine (FLX) in aquatic environments has been rising constantly. The aim of the present study is to evaluate the combined toxicity of a serotonin reuptake inhibitor (FLX) and Zn2+ on a non-target aquatic model organism Daphnia magna. Animals were exposed to single and binary combinations of FLX (20.5 and 41 µg/L for subchronic and 41 and 82 µg/L for acute exposures) and Zn2+ (40 µg/L for subchronic and 80 µg/L for acute exposures). In vivo experiments were done for 7 days subchronic and 48 h acute exposure, while subcellular supernatants of whole Daphnia lysate (WDL) were directly treated with the same concentrations used in the acute experiments. Morphological characteristics, Ca2+-ATPase, antioxidant enzyme activities, and lipid peroxidation were examined. There was antioxidant system suppression and Ca2+-ATPase inhibition despite the diverse response patterns due to duration, concentration, and toxicant type. After acute exposure, biomarkers showed a diminishing trend compared to subchronic exposure. According to integrated biomarker response index (IBR) analysis, in vivo Zn2+ exposure was reasonably effective on the health of D. magna, whereas exposure of WDL to Zn2+ had a lesser impact. FLX toxicity increased in a concentration-dependent manner, reversed by the combined exposure. We concluded that potential pro-oxidative and adverse Ca2+-ATPase effects of FLX and Zn2+ in D. magna may also have harmful impact on ecosystem levels. Pharmaceutical exposure (FLX) should be considered along with their potential to interact with other toxicants in aquatic biota. Graphical Abstract

show abstract