Ecotoxicological Evaluation of Perfluorooctanesulfonate (PFOS)

Effects of perfluorooctane sulfonate on ion channels and glutamate-activated current in cultured rat hippocampal neurons

“…Recent studies have proved various toxicities of PFOS in animals (Lau et al, 2004(Lau et al, , 2007Kennedy et al, 2004;Beach et al, 2006). In the previous work (Liao et al, 2008), we revealed that acute perfusion of PFOS (10 M and above) rapidly enhanced synaptic activity in both cultured hippocampal neurons and hippocampal brain slices, while chronic treatment with PFOS (50 M) moderately inhibited neurite outgrowth and dramatically suppressed synaptogenesis in cultured neurons.…”

Perfluoroalkyl substances and organochlorine pesticides in sediments from Huaihe watershed in China

“…Predicted no-effect concentration (PNEC) was used as a threshold value for protecting wildlife and as a parameter for the ecological risk assessment of pollutants (Beach et al, 2006;Giesy et al, 2010). In this study, PNECs of PFOA and PFOS in sediments were suggested based on the equilibrium partitioning method, using the PNECs in freshwater and distribution coefficient (K d ) (Zushi et al, 2012).…”

Effect of salinity and sediment characteristics on the sorption and desorption of perfluorooctane sulfonate at sediment-water interface

“…Recently, the environmental fate of PFOS has raised public and scientific concerns for its high bioaccumulation, extreme persistence, and toxic properties, such as endocrine-disrupting activity and carcinogenesis (Beach et al, 2006). Many studies have shown that PFOS is ubiquitously detected in the environment, even in remote arctic areas (Giesy and Kannan, 2001;Report RIKZ/ 2002.043, 2002.…”