Ecotoxicological QSARs of Personal Care Products and Biocides

Khan, Kabiruddin; Sanderson, Hans; Roy, Kunal

doi:10.1007/978-1-0716-0150-1_16

Cited by 6 publications

(2 citation statements)

References 56 publications

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“…Although PCPs are safe for human use, the scarcity of environmental evaluations and tests before they are placed on sale means that there is a lack of regulations that indicate their impact on the environment [77][78][79]. Table 1 displays a list of some personal care products together with their toxic components and the impact that these causes on the environment.…”

Section: Methodsmentioning

confidence: 99%

Sustainable Treatment Techniques for Emerging Pollutants—The Case of Personal Hygiene Products

et al. 2022

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Personal care products (PCPs) enter wastewater primarily through greywater. Treatment plants have not been able to remove this type of contaminant, although PCP abatement techniques have been developed in recent years. The objective of the current study has been to encounter the sustainable technique that keeps the optimal balance between the criteria considered in the comparison. Therefore, a bibliographic review was conducted in scientific databases of the last eight years, demonstrating that co-composting, anaerobic–aerobic sequencing bioreactors and contaminant absorption through the use of carbon nanotubes are the ones with the least environmental impact. Subsequently, the Saaty and Modified Saaty methods were applied, with a comparative criteria of construction costs, maintenance costs, efficiency and the stage of development. The results indicated that the co-composting technique is the best sustainable technique of those studied, with a score of 0.86/1, which means that the criteria analyzed maintain very close values between them. The co-composting technique yields a low environmental impact in eliminating personal care products. This research work constitutes a practical and easy-to-use tool for decision makers, since it allows finding an optimal elimination treatment for PCPs.

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Section: Methodsmentioning

confidence: 99%

Sustainable Treatment Techniques for Emerging Pollutants—The Case of Personal Hygiene Products

et al. 2022

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“…These data provide valuable resources for building some in silico models to assess the covert of skin sensitization. In addition, the skin sensitization QSAR models can be applied to not only cosmetic ingredients but also the compound, which can impact the ecosystems such as dye pollution, the effect of personal care products on aquatic species, or plasticizers (Arulanandam et al, 2021;Funar-Timofei and Ilia, 2020;Khan et al, 2020) as well as the pharmacokinetics profiles of low molecular weight oligohydroxyalkanoates (Roman et al, 2020), suggesting that the skin sensitization models has a wide range of applications. To date, most of the published skin sensitization models are qualitative predictions, viz.…”

Section: Future Perspectivesmentioning

confidence: 99%

In silico Prediction of Skin Sensitization: Quo vadis?

Weng²,

Leong

2021

Front. Pharmacol.

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Skin direct contact with chemical or physical substances is predisposed to allergic contact dermatitis (ACD), producing various allergic reactions, namely rash, blister, or itchy, in the contacted skin area. ACD can be triggered by various extremely complicated adverse outcome pathways (AOPs) remains to be causal for biosafety warrant. As such, commercial products such as ointments or cosmetics can fulfill the topically safe requirements in animal and non-animal models including allergy. Europe, nevertheless, has banned animal tests for the safety evaluations of cosmetic ingredients since 2013, followed by other countries. A variety of non-animal in vitro tests addressing different key events of the AOP, the direct peptide reactivity assay (DPRA), KeratinoSens™, LuSens and human cell line activation test h-CLAT and U-SENS™ have been developed and were adopted in OECD test guideline to identify the skin sensitizers. Other methods, such as the SENS-IS are not yet fully validated and regulatorily accepted. A broad spectrum of in silico models, alternatively, to predict skin sensitization have emerged based on various animal and non-animal data using assorted modeling schemes. In this article, we extensively summarize a number of skin sensitization predictive models that can be used in the biopharmaceutics and cosmeceuticals industries as well as their future perspectives, and the underlined challenges are also discussed.

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Chemometric Modeling of Toxicity of Chemicals to Tadpoles

Khan

Roy

2021

Chemometrics and Cheminformatics in Aquatic Toxicology

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Ecotoxicological QSARs of Personal Care Products and Biocides

Cited by 6 publications

References 56 publications

Sustainable Treatment Techniques for Emerging Pollutants—The Case of Personal Hygiene Products

Sustainable Treatment Techniques for Emerging Pollutants—The Case of Personal Hygiene Products

In silico Prediction of Skin Sensitization: Quo vadis?

Chemometric Modeling of Toxicity of Chemicals to Tadpoles

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