Ecotoxicological response of zebrafish liver (Danio rerio) induced by di-(2-ethylhexyl) phthalate

Li, Xianxu; Wang, Qian; Wang, Can; Yang, Zhongkang; Wang, Jinhua; Zhu, Lusheng; Zhang, Dexin; Wang, Jun

doi:10.1016/j.ecolind.2022.109388

Cited by 12 publications

(1 citation statement)

References 46 publications

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“…Analysis of chemical additives in the polymers studied here identified three main additives in the PET, including two plasticizers (Bis(2-ethylhexyl)isophthalate; DEHP, and ethylhexyl thioglycolate) and the dye used to color the fabric orange (Coumarin 7). Both plasticizers identified have been noted as significant environmental and human toxins [112][113][114][115] and likely play a role in the impacts observed to tubificid worms. Given the critical role of benthic organisms as ecosystem engineers (e.g., [19]), an additional study investigating the mechanism of toxicity across polymers (i.e., morphology, chemical composition, ingestion, entanglement) is needed to fully understand the impact of plastic pollution in waterways.…”

Section: Pet Impacts Ecosystem Metabolismmentioning

confidence: 99%

Impact of Microplastic on Freshwater Sediment Biogeochemistry and Microbial Communities Is Polymer Specific

Chomiak,

Owens-Rios,

Bangkong

et al. 2024

Water

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Plastic debris is a growing threat in freshwater ecosystems and transport models predict that many plastics will sink to the benthos. Among the most common plastics found in the Laurentian Great Lakes sediments are polyethylene terephthalate (especially fibers; PET), polyvinylchloride (particles; PVC), and styrene-butadiene rubber resulting from tire wear (“crumb rubber”; SBR). These materials vary substantially in physical and chemical properties, and their impacts on benthic biogeochemistry and microbial community structure and function are largely unknown. We used a microcosm approach to evaluate the impact of these three plastics on benthic-pelagic coupling, sediment properties, and sediment microbial community structure and function using sediments from Irondequoit Bay, a major embayment of Lake Ontario in Rochester, New York, USA. Benthic metabolism and nitrogen and phosphorous cycling were all uniquely impacted by the different polymers. PET fibers and PVC particles demonstrated the most unique effects, with decreased ecosystem metabolism in sediments containing PET and greater nutrient uptake in sediments with PVC. Microbial diversity was reduced in all treatments containing plastic, but SBR had the most substantial impact on microbial community function, increasing the relative importance of metabolic pathways such as hydrocarbon degradation and sulfur metabolism. Our results suggest that individual polymers have unique impacts on the benthos, with divergent implications for ecosystem function. This provides deeper insight into the myriad ways plastic pollution may impact aquatic ecosystems and will help to inform risk assessment and policy interventions by highlighting which materials pose the greatest risk.

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Section: Pet Impacts Ecosystem Metabolismmentioning

confidence: 99%

Impact of Microplastic on Freshwater Sediment Biogeochemistry and Microbial Communities Is Polymer Specific

Chomiak,

Owens-Rios,

Bangkong

et al. 2024

Water

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Chronic exposure to bisphenol A induces behavioural, neurochemical, histological, and ultrastructural alterations in the ganglia tissue of the date mussels Lithophaga lithophaga

Abd Elkader,

Al-Shami

2023

Environ Sci Pollut Res

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Bisphenol A (BPA), a common plastic additive, has been demonstrated mechanistically to be a potential endocrine disruptor and to affect a variety of body functions in organisms. Although previous research has shown that BPA is toxic to aquatic organisms, the mechanism of neurotoxic effects in marine bivalves remains unknown. The current study aimed to elucidate the neurotoxic effects of BPA when administered at different concentrations (0.25, 1, 2, and 5 µg/L) for twenty-eight days in the ganglia of a bivalve model, the Mediterranean mussel (Lithophaga lithophaga), which is an ecologically and economically important human food source of bivalve species in the Mediterranean Sea. Our findings revealed an increase in behavioural disturbances and malondialdehyde levels in treated mussel ganglia compared to the control group. Furthermore, superoxide dismutase activity increased in the ganglia of L. lithophaga treated with 0.25 and 2 µg/L. However, at BPA concentrations of 1 and 5 µg/L, SOD activity was significantly reduced, as was total glutathione concentration. BPA causes neurotoxicity, as evidenced by concentration-dependent inhibition of acetylcholinesterase, dopamine, and serotonin. After chronic exposure to BPA, neurons showed distortion of the neuronal cell body and varying degrees of pyknosis. The ultrastructure changes in BPA-treated groups revealed the lightening of the nucleoplasm and a shrunken nuclear envelope. Overall, our findings suggest that BPA exposure altered antioxidation, neurochemical biomarkers, histopathological, and ultrastructural properties, resulting in behavioural changes. As a result, our findings provide a basis for further study into the toxicity of BPA in marine bivalves.

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Acetylcholinesterase and dopamine inhibition suppress the filtration rate, burrowing behaviours, and immunological responses induced by bisphenol A in the hemocytes and gills of date mussels, Lithophaga lithophaga

Elkader,

Al-Shami

2024

Aquatic Toxicology

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Ecotoxicological response of zebrafish liver (Danio rerio) induced by di-(2-ethylhexyl) phthalate

Cited by 12 publications

References 46 publications

Impact of Microplastic on Freshwater Sediment Biogeochemistry and Microbial Communities Is Polymer Specific

Impact of Microplastic on Freshwater Sediment Biogeochemistry and Microbial Communities Is Polymer Specific

Chronic exposure to bisphenol A induces behavioural, neurochemical, histological, and ultrastructural alterations in the ganglia tissue of the date mussels Lithophaga lithophaga

Acetylcholinesterase and dopamine inhibition suppress the filtration rate, burrowing behaviours, and immunological responses induced by bisphenol A in the hemocytes and gills of date mussels, Lithophaga lithophaga

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