Ecotoxicology inside the gut: impact of heavy metals on the mouse microbiome

Breton, Jérôme; Massart, Sébastien; Vandamme, Peter; Brandt, Evie De; Pot, Bruno; Foligné, Benoît

doi:10.1186/2050-6511-14-62

Cited by 194 publications

(133 citation statements)

References 30 publications

(33 reference statements)

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“…The gastrointestinal tract absorbs a small part of cadmium, and a majority of cadmium remain in the intestinal mucosa (Andersen et al 1988). Breton et al found that non-absorbed cadmium had a direct impact on mouse gut microbiota and in turn impact the alimentary tract and overall gut homeostasis (Breton et al 2013). For these reasons, we conjectured that cadmium exposure may lead to loss of weight due to impaired absorption function of gastrointestinal tract.…”

Section: Discussionmentioning

confidence: 95%

Blood cadmium in Chinese adults and its relationships with diabetes and obesity

Nie

Wang

Chen

et al. 2016

Environ Sci Pollut Res

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The aim of this study is to evaluate blood cadmium levels (BCLs) in Chinese adults and explore whether blood cadmium is associated with diabetes or obesity. This study included 5544 adults from a cross-sectional SPECT-China study. BCL and blood lead level (BLL) was measured by atomic absorption spectrometry. Fasting plasma glucose (FPG) was used to define prediabetes and diabetes. Overweight and obesity were defined by body mass index (BMI). The associations of BCL with prediabetes, diabetes, overweight, and obesity were analyzed by multinomial logistic regression analyses. Medians (interquartile range) of BCL were 1.97 μg/L (0.60-3.82) in men and 1.59 μg/L (0.54-3.51) in women. Subjects in low-economic-status areas and urban areas had significantly higher BCL. BCL in current smokers was significantly higher than in current non-smokers. In the adjusted model, a mild positive relationship between BCL and FPG was found. Meanwhile, the prevalence of prediabetes was increased according to the increase in BCL tertiles. Surprisingly, BCL had a negative relationship with prevalence of overweight. In conclusion, BCL in Chinese adults was much higher than in other developed countries and was influenced by gender, smoking, and residential area. BCL was positively related to prediabetes while negatively related to overweight.

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Section: Discussionmentioning

confidence: 95%

Blood cadmium in Chinese adults and its relationships with diabetes and obesity

Nie

Wang

Chen

et al. 2016

Environ Sci Pollut Res

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“…72 Other studies, 454 using higher doses than ours, reported oral Pb exposure effects on the gut microbiota 455 composition mediated by non-absorbed heavy metals or before their absorption. 73 In Pb 456 exposed partridges, the high concentration of Pb in the intestine several weeks after 457 exposure and Pb effects on constitutive immunity are both likely mechanisms 458 explaining observed changes in the gut bacteria. 459…”

Section: Nabs Enhance Antigen Presentation and Initiate Specific Respmentioning

confidence: 98%

Sublethal Pb Exposure Produces Season-Dependent Effects on Immune Response, Oxidative Balance and Investment in Carotenoid-based Coloration in Red-Legged Partridges

Vallverdú-Coll

Ortiz‐Santaliestra

Mougeot

et al. 2015

Environ. Sci. Technol.

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Ingestion of lead (Pb) shot pellets constitutes the main cause of Pb poisoning in avifauna. We studied the effects of sublethal Pb exposure on immunity, carotenoid-based coloration, oxidative stress and trade-offs among these types of responses during spring and autumn in red-legged partridges (Alectoris rufa). We evaluated constitutive immunity testing lysozyme and natural antibody levels, and blood bactericidal and phagocytic activities. We studied induced immunity by testing PHA and humoral responses. We analyzed fecal parasite and bacterial abundance and oxidative stress biomarkers. Pb exposure in spring reduced natural antibody levels, whereas in autumn, it reduced lysozyme levels and increased phagocytic activity. Pb exposure increased PHA response in both seasons, and decreased T-independent humoral response in autumn. Pb exposure also increased noncoliform and decreased coliform Gram-negative gut bacteria. In spring, Pb exposure decreased antioxidant levels and increased coloration in males, whereas in autumn, it increased retinol levels but reduced coloration in both genders. Our results suggest that in spring, Pb-exposed females used antioxidants to cope with oxidative stress at the expense of coloration, whereas Pb-exposed males increased coloration, which may reflect an increased breeding investment. In autumn, both genders prioritized oxidative balance maintenance at the expense of coloration.

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“…There are relatively few studies that examine the role of environmental contaminants on the human microbiome or in model systems (10)(11)(12) and even fewer that address this in wildlife. One such study indicates that arsenic exposure in drinking water can alter the composition of gut microbiota in mice and the subsequent suite of metabolites produced by the microbes, thereby potentially altering the function of this complex symbiotic community (11).…”

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confidence: 99%

Short-Term Exposure to Coal Combustion Waste Has Little Impact on the Skin Microbiome of Adult Spring Peepers (Pseudacris crucifer)

Hughey

Walke

Becker

et al. 2016

Appl Environ Microbiol

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Disruptions to the microbiome can impact host health as can exposure to environmental contaminants. However, few studies have addressed how environmental contaminants impact the microbiome. We explored this question for frogs that breed in wetlands contaminated with fly ash, a by-product of coal combustion that is enriched in trace elements. We found differences in the bacterial communities among a fly ash-contaminated site and several reference wetlands. We then experimentally assessed the impacts of fly ash on the skin microbiome of adult spring peepers (Pseudacris crucifer). Frogs were exposed to fly ash in the laboratory for 12 h, the duration of a typical breeding event, and the skin microbiome was assessed after 5 days (experiment 1) or after 5 and 15 days (experiment 2). We examined bacterial community structure using 16S rRNA gene amplicon sequencing and metabolite profiles using high-pressure liquid chromatography-mass spectrometry (HPLC-MS). We found little impact as the result of acute exposure to fly ash on the bacterial communities or metabolite profiles in either experiment, suggesting that the bacterial symbiont communities of adults may be relatively resistant to brief contaminant exposure. However, housing frogs in the laboratory altered bacterial community structure in the two experiments, which supports prior research suggesting that environmental source pools are important for maintaining the amphibian skin microbiome. Therefore, for contaminants like fly ash that may alter the potential source pool of symbionts, we think it may be important to explore how contaminants affect the initial assembly of the amphibian skin microbiome in larval amphibians that develop within contaminated sites. IMPORTANCEAnimals are hosts to many symbiotic microorganisms, collectively called the microbiome, that play critical roles in host health. Therefore, environmental contaminants that alter the microbiome may impact hosts. Some of the most widespread contaminants, produced worldwide, are derived from the mining, storage, and combustion of coal for energy. Fly ash, for example, is a by-product of coal combustion. It contains compounds such as arsenic, selenium, cadmium, and strontium and is a recognized source of ground and surface water contamination. Here, we experimentally investigated the impacts of short-term fly ash exposure on the skin microbiome of spring peepers, one of many species of amphibian that sometimes breed in open fly ash disposal ponds. This research provides a look into the potential impacts of fly ash on an animal's microbiome and suggests important future directions for research on the effects of environmental contaminants on the microbiome. Vertebrates host a wide array of symbiotic microorganisms, mainly in the gut, but there are unique microbial communities spread throughout the body from the nasal cavity to the lungs to the skin (1). While we have long understood that the microbiota residing in the gut are diverse and are important in helping to digest food, only recently have...

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Ecotoxicology inside the gut: impact of heavy metals on the mouse microbiome

Cited by 194 publications

References 30 publications

Blood cadmium in Chinese adults and its relationships with diabetes and obesity

Blood cadmium in Chinese adults and its relationships with diabetes and obesity

Sublethal Pb Exposure Produces Season-Dependent Effects on Immune Response, Oxidative Balance and Investment in Carotenoid-based Coloration in Red-Legged Partridges

Short-Term Exposure to Coal Combustion Waste Has Little Impact on the Skin Microbiome of Adult Spring Peepers (Pseudacris crucifer)

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