Ecstasy induced hepatitis mimicking viral hepatitis.

Dykhuizen, R S; Brunt, P. W.; Atkinson, Prescott; Simpson, John G.; Smith, C. C.

doi:10.1136/gut.36.6.939

Cited by 77 publications

(35 citation statements)

References 11 publications

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“…Hepatic injury was defined as a serum aspartate transaminase or alanine transaminase level greater than 1000 U/L. 10,11 Acute kidney injury was characterized by a rise in serum creatinine by at least 50% or at least 26.4 mmol/L from predicted baseline, or a urine output of less than 0.5 mL/kg per hour over 6 hours. 12 Rhabdomyolysis was defined as a creatine kinase level greater than 1000 U/L or more than 5 times the upper limit of normal.…”

Section: Data Collection and Definitionsmentioning

confidence: 99%

Deaths from exposure to paramethoxymethamphetamine in Alberta and British Columbia, Canada: a case series

et al. 2015

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Section: Data Collection and Definitionsmentioning

confidence: 99%

Deaths from exposure to paramethoxymethamphetamine in Alberta and British Columbia, Canada: a case series

et al. 2015

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“…Severe hepatotoxicity may be a concomitant. [60][61][62][63][64] MDMA is metabolized by CYP2D6; a rat model with deficient enzyme exhibited an elevated thermal response to MDMA, 65 suggesting that genetically poor hydroxylators (Ϸ5% of whites) with decreased CYP2D6 may be predisposed to MDMA-related hyperthermia and possibly hepatotoxicity. However, human data to support this hypothesis are lacking.…”

Section: Drugs Of Abusementioning

confidence: 99%

“…[60][61][62][63][64] These occurred after incidental or regular ingestion with variable latency of days to weeks. An eosinophilic infiltrate was seen occasionally in the portal tracts.…”

Section: Drugs Of Abusementioning

confidence: 99%

Hepatotoxicity of Psychotropic Drugs

1999

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“…En cuanto a las consecuencias de su consumo, existen numerosas comunicaciones acerca de los importantes efectos tóxicos del MDMA y sus derivados, que pueden producir reacciones adversas agudas intensas, incluso mortales (62). Se sabe que el "éxta-sis" y otros derivados anfetamínicos pueden originar cuadros neurológicos mixtos entre el síndrome neuroléptico maligno y el síndrome serotoninérgico, cuadros psicóticos (63), alteraciones renales (64) y hepáticas (65,66). No obstante, hasta el presente, no se conoce la influencia que en tales u otros efectos pudiera tener el consumo simultáneo de metadona.…”

Section: Cánnabis Y éXtasisunclassified

Interacciones de metadona con fármacos antiinfecciosos y sustancias de abuso

et al. 2000

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Resumen:Frecuentemente es necesario utilizar antiinfecciosos en pacientes tratados con metadona. Se han observado diversas interacciones entre metadona y fármacos antiinfecciosos, siendo necesaria una especial vigilancia en caso de tratamiento antirretroviral. Se ha descrito aumento de los niveles plasmáticos y de la toxicidad de zidovudina por metadona; también es posible el efecto contrario, es decir la disminución de los efectos del opiáceo por la zidovudina. Entre los inhibidores de la proteasa, ritonavir puede aumentar considerablemente los niveles plasmáticos de metadona y sus efectos depresores. Eritromicina o ketoconazol tienen efectos farmacocinéticos similares. Al contrario, se ha observado el desencadenamiento de síndrome de abstinencia debido a inducción metabólica originada por rifampicina. También las sustancias de abuso, frecuentemente utilizadas por estos pacientes, pueden originar interacciones farmacológicas. La significación clínica de la interacción alcohol/metadona no está clara, en ella pueden participar modificaciones en el metabolismo hepático. A pesar del extenso abuso de cocaí-na en estos pacientes, son poco conocidas las consecuencias de su consumo con metadona, en las que pudieran estar implicadas interacciones entre la neurotransmisión catecolaminérgica y opioidergica. Se requieren más estudios sobre cannabinoides, anfetaminas o drogas de diseño, de frecuente consumo en esta población.Palabras clave: Metadona. Interacciones farmacológicas. Drogas de abuso. Alcohol. Antiinfecciosos. Nicotina. Summary:Antiinfection therapy is frequently needed in patients undergoing methadone treatment. Interactions between methadone and antiinfectious drugs occur and antirretroviral treatment must be closely monitored. It is known that zidovudine levels and hence toxicity may be increased by methadone; conversely, xidovudine may decrease the opiate effect. Among the protease inhibitors, ritonavir is likely considerably to increase plasma levels of methadone and its depressive effects. Erythromycin or ketoconazole may also raise methadone plasma concentrations. On the other hand, methadone withdrawal symptoms have been reported in addicts treated with the tuberculostatic rifampicin, due to the induction of the drug metabolism. Different types of abuse substances are also commonly used in opiate-dependent patients. These substances may also cause interactions with methadone. The clinical significance of alcohol and methadone combinaton remains uncertain, although alterations in hepatic metabolism may be implicated. Abuse of cocaine in methadone-maintained patients has been extensively reported. The consequences of cocaine consumption on maintenance treatments are not clear, although catecholaminergic modulation of opioidergic neurotransmission could play and important role. Although they are also widely consumed by patients on methadone therapy, little is known about the final consequences of cannabinoids, amphetamines or novel "designer drugs" on methadone treatments.

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Ecstasy induced hepatitis mimicking viral hepatitis.

Cited by 77 publications

References 11 publications

Deaths from exposure to paramethoxymethamphetamine in Alberta and British Columbia, Canada: a case series

Deaths from exposure to paramethoxymethamphetamine in Alberta and British Columbia, Canada: a case series

Hepatotoxicity of Psychotropic Drugs

Interacciones de metadona con fármacos antiinfecciosos y sustancias de abuso

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