“…There is a general consensus, however, that potential options include (1) augmentation with psychotherapy (De Jonghe et al, 2004), (2) switching classes of medication (McGrath et al, 1993), (3) supplementation with a second antidepressant of a different class (Bodkin et al, 1997;Gomez Gomez and Teixido Perramon, 2000), (4) somatic therapy such as rapid transcranial magnetic stimulation, electroconvulsive therapy, or vagal-nerve stimulation (Figiel et al, 1998;Rush et al, 2000;Wahlund and von Rosen, 2003), and (5) augmentation strategies with agents usually not considered as classical antidepressants, such as lithium (Fava, 2001) or thyroid hormone (Joffe et al, 1993). One augmentation strategy that has recently been explored is supplementation of antidepressants with atypical antipsychotic medications (Ostroff and Nelson, 1999;Shelton et al, 2001;Adson et al, 2004;Papakostas et al, 2004).…”