ECT Treatment for Two Cases of Dementia-Related Pathological Yelling

Bang, Benedicte; Price, Daniel; Prentice, Glenn; Campbell, John J.

doi:10.1176/jnp.2008.20.3.379

Cited by 37 publications

(12 citation statements)

References 7 publications

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“…Bang and colleagues (Bang et al, 2008) described two cases of improvement in agitation in patients with dementia with the use of ECT. The first case was an 88-year-old female, in the USA, with a six-year history of "probable" Alzheimer's dementia and Parkinson's disease.…”

Section: Case Seriesmentioning

confidence: 99%

Electroconvulsive therapy (ECT) for treating agitation in dementia (major neurocognitive disorder) – a promising option

Glass

Forester

Hermida

2017

Int. Psychogeriatr.

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Available studies are often limited by concomitant psychotropic medications, inconsistent use of objective rating scales, short follow-up, lack of a control group, small sample sizes, and publication bias. A future randomized controlled trial will pose ethical and methodological challenges. A randomized controlled trial must carefully consider the definition of usual care as a comparison group. Well-documented prospective studies and/or additional case series with explicit selection criteria, a wide range of outcome measures, and less selection bias of the study sample that may favor treatment response, is warranted. ECT may be a promising option for the treatment of aggression and agitation in patients with severe dementia who are refractory to other treatment options, but the limitations of available studies suggest that a cautious approach to future randomized controlled trials is warranted.

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Section: Case Seriesmentioning

confidence: 99%

Electroconvulsive therapy (ECT) for treating agitation in dementia (major neurocognitive disorder) – a promising option

Glass

Forester

Hermida

2017

Int. Psychogeriatr.

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“…Electroconvulsive therapy (ECT) has been found to be safe and effective in the treatment of depression and mania in older adults, with and without dementia (Nelson and Rosenberg, 1991;Tomac et al, 1997;Tew et al, 1999;Rao and Lyketsos, 2000;McDonald & Thompson, 2001;Weintraub and Lippman, 2001;Stoppe et al, 2006). The few published reports that investigated the use of ECT for the treatment of agitation in dementia have been case studies and retrospective chart reviews that provided support for the utility of ECT as a safe and beneficial intervention strategy (Roccaforte et al, 2000;Grant and Mohan, 2001;Bang et al, 2008;Sutor and Rasmussen, 2008;Ujkaj et al, 2010). A major concern for using ECT in older patients, especially those with dementia, is its adverse effect on cognitive functioning.…”

Section: Introductionmentioning

confidence: 99%

Safety and utility of acute electroconvulsive therapy for agitation and aggression in dementia

Acharya

Harper

Achtyes

et al. 2014

Int J Geriatr Psychiatry

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Objective Agitation and aggression are among the most frequent and disruptive behavioral complications of dementia that contribute to increased cost of care, hospitalization, caregiver burden, and risk of premature institutionalization. This current study examined the safety and efficacy of electroconvulsive therapy (ECT) as a treatment for behavioral disturbances in dementia. We hypothesized that ECT would result in reduced agitated and aggressive behaviors between baseline and discharge. Methods Twenty-three participants admitted to McLean Hospital (Belmont, MA) and Pine Rest Christian Mental Health Services (Grand Rapids, MI), with a diagnosis of dementia who were referred for ECT to treat agitation and/or aggression, were enrolled in the study. We administered the Cohen-Mansfield Agitation Inventory (CMAI)-short form, Neuropsychiatric Inventory (NPI)-Nursing Home Version, Cornell Scale for Depression in Dementia (CSDD), and the Clinical Global Impression Scale (CGI) at baseline, during, and after the ECT course. Results Regression analyses revealed a significant decrease from baseline to discharge on the CMAI (F(4, 8) =13.3; p=0.006) and NPI (F(4, 31)= 14.6; p<0.001). There was no statistically significant change in scores on the CSDD. The CGI scores on average changed from a rating of “markedly agitated/aggressive” at baseline to “borderline agitated/aggressive” at discharge. Treatment with ECT was well tolerated by most participants; discontinuation of ECT occurred for two participants due to recurrence of agitation and for three participants due to adverse events. Conclusions ECT may be a safe treatment option to reduce symptoms of agitation and aggression in patients with dementia whose behaviors are refractory to medication management.

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“…An earlier case report by Roccaforte and colleagues showed that ECT was effective for a 77-year-old-female patient with advanced dementia and disruptive verbal agitation described as "screaming dementia." 34 A more recent case series, reported by Sutor and Rasmussen, describes the efficacy of ECT in 11 agitated the AD patients (10 women). 22 Another case series reports four demented patients with agitation and aggression treated successfully with bilateral ECT after failing pharmacological treatment.…”

Section: Discussionmentioning

confidence: 99%

Safety and Efficacy of Electroconvulsive Therapy for the Treatment of Agitation and Aggression in Patients With Dementia

Ujkaj

Davidoff

Seiner

et al. 2012

The American Journal of Geriatric Psychiatry

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ECT Treatment for Two Cases of Dementia-Related Pathological Yelling

Cited by 37 publications

References 7 publications

Electroconvulsive therapy (ECT) for treating agitation in dementia (major neurocognitive disorder) – a promising option

Electroconvulsive therapy (ECT) for treating agitation in dementia (major neurocognitive disorder) – a promising option

Safety and utility of acute electroconvulsive therapy for agitation and aggression in dementia

Safety and Efficacy of Electroconvulsive Therapy for the Treatment of Agitation and Aggression in Patients With Dementia

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