Ecteinascidins 729, 743, 745, 759A, 759B, and 770: potent antitumor agents from the Caribbean tunicate Ecteinascidia turbinata

Rinehart, Kenneth L.; Holt, Tom G.; Fregeau, Nancy L.; Stroh, Justin G.; Keifer, Paul A.; Sun, Fu-Rong; Li, Li H.; Martin, David G.

doi:10.1021/jo00302a007

Cited by 457 publications

(240 citation statements)

References 1 publication

(1 reference statement)

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“…Ecteinascidin (ET-743) is a marine alkaloid derived from the Caribbean sea squirt, E Turbinata, being developed by Pharma Mar, Madrid, Spain (Rinehart et al, 1990). The drug exhibits a potent and an unique mechanism of cytotoxicity in a variety of human cancer cell lines and xenografts including leukemia, melanoma, ovarian, sarcoma, breast and lung tumors (Jimeno et al, 1996).…”

Section: A Minor-grove Dna Inhibitor Et-743mentioning

confidence: 99%

New agents in cancer clinical trials

Adams

Elliott

2000

Oncogene

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Section: A Minor-grove Dna Inhibitor Et-743mentioning

confidence: 99%

New agents in cancer clinical trials

Adams

Elliott

2000

Oncogene

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“…The lead compound, trabectedin (ET-743, 84), is regarded as a successful story of modern marine drug research: it is indeed the first representative of a marine natural product to receive marketing authorization for the treatment of patients with advanced or metastatic soft tissue sarcomas (STS) and relapsed platinum-sensitive ovarian cancer under the brand name Yondelis (87), and ET 770 (88), was reported by the Rinehart group in 1990, of which ET-743 was the most abundant representative [67]. Simultaneously, Wright and co-workers described compounds 83 and 84 [68], but the unequivocal assignment of the absolute stereochemistry was achieved only when the X-ray crystal structures of the natural N…”

Section: Tetrahydroisoquinoline Alkaloids: Ecteinascidins a New Clasmentioning

confidence: 99%

Alkaloids from Marine Invertebrates as Important Leads for Anticancer Drugs Discovery and Development

et al. 2014

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Abstract:The present review describes research on novel natural antitumor alkaloids isolated from marine invertebrates. The structure, origin, and confirmed cytotoxic activity of more than 130 novel alkaloids belonging to several structural families (indoles, pyrroles, pyrazines, quinolines, and pyridoacridines), together with some of their synthetic analogs, are illustrated. Recent discoveries concerning the current state of the potential and/or development of some of them as new drugs, as well as the current knowledge regarding their modes of action, are also summarized. A special emphasis is given to the role of marine invertebrate alkaloids as an important source of leads for anticancer drug discovery.

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“…Some compounds can be completely synthesized, whereas others may have their structure modified to increase their potency and/ or reduce toxicity. For example, semisynthetic routes have been developed to obtain ET-743, based on the precursor safracin B from the bacteria Pseudomonas flourescens (Cuevas et al, 2000), halichondrin B (Hart et al, 2000), and kalahide F (Lopez-Macia et al, 2001) to supply these anti-cancer compounds found in the ascidia Ecteinascidia turbinata (Rinehart et al, 1990), the sponge Lissodendoryx sp (Hart et al, 2000), and the green seaweed Bryopsis sp. (Newman & Cragg, 2004), respectively.…”

Section: Supply Problem and Alternativesmentioning

confidence: 99%

Bioprospecting for bioactives from seaweeds: potential, obstacles and alternatives

Pereira¹,

Costa-Lotufo²

2012

Rev. bras. farmacogn.

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Seaweeds are potential sources of high biotechnological interest due to production of a great diversity of compounds exhibiting a broad spectrum of biological activities. On the other hand, there is an urgent need for management options for a sustainable approach to the use of marine organisms as a source of bioactive compounds. This review discusses the bioprospection for bioactive seaweed compounds as pharmaceuticals and antifouling agents, encompassing their potential and possible obstacles and alternatives. In spite of their potential, research on pharmaceuticals and antifouling agents from seaweeds includes mainly the search for molecules that exhibit these biological activities, but lacks of consideration of fundamental and limiting aspects such as the development of alternatives to sustainable supply. However, for the complete development of pharmaceuticals and antifouling compounds in Brazil, marine bioprospection should be more comprehensive, associating the search for molecules with an analysis of their supply. In this way, it is possible to promote sustainable development and conservation of biodiversity, as well as to assert the economic development of Brazil.

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Ecteinascidins 729, 743, 745, 759A, 759B, and 770: potent antitumor agents from the Caribbean tunicate Ecteinascidia turbinata

Cited by 457 publications

References 1 publication

New agents in cancer clinical trials

New agents in cancer clinical trials

Alkaloids from Marine Invertebrates as Important Leads for Anticancer Drugs Discovery and Development

Bioprospecting for bioactives from seaweeds: potential, obstacles and alternatives

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