Ecthyma Gangrenosum: A Rare Cutaneous Manifestation Caused by Pseudomonas Aeruginosa Without Bacteraemia in a Leukaemic Patient- A Case Report

Singh, TN; Devi, K. Saranya

doi:10.1016/s0255-0857(21)02534-2

Cited by 24 publications

(3 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…5 Although the gluteal or perineal region is the most typical location for EG lesions (57%), other unusual locations can also be affected, including the extremities, trunk, face, and very infrequently the periorbital region. 4 Our patient had lesions that appeared as nodules with a central crust and round, ulcerated, necrotic papules. The left forehead, left side of the chest, and area next to the breasts were all affected by the lesions.…”

Section: Discussionmentioning

confidence: 77%

See 1 more Smart Citation

An Infant with Measles Developed Ecthyma Gangrenosum Caused by Coagulase-Negative Staphylococcus: A Rare Case Report from Somalia

Ali,

Mohamed,

Hirsi

et al. 2023

IMCRJ

View full text Add to dashboard Cite

Ecthyma gangrenosum is a skin lesion that can be caused by either bacterial hematogenous seeding or a primary skin infection. Despite being the most frequent causal agent, Pseudomonas aeruginosa is not the only bacteria that has been involved. Other types of bacteria may also be implicated in the etiology of EG: cocci bacteria, both gram-positive and gram-negative. Case Presentation: Here, we report the case of a 10-month-old male infant who developed ecthyma gangrenosum after a measles infection. At the time of admission, the patient had a high fever of about 40.3°C and appeared conscious. Physical examination revealed several skin lesions that were in various stages of development and appeared as nodules with a central crust and round, ulcerated, necrotic papules in the face, chest, and upper extremities. Laboratory tests showed CRP of 25 mg/l, LDH of 579 U/L, WBC of 15.06 × 1000/mm3, and absolute neutrophils of 1930/mm3 (12.8%). The result of the culture showed coagulase-negative Staphylococcus. According to the drug susceptibility test results, intravenous Vancomycin (20 mg/kg per dose, 3 times daily) should be started. A coagulase-negative Staphylococcus was eliminated as a result of this defervescence. The necrotic lesion was surgically removed from the patient. Clinical Discussion: Ecthyma gangrenosum is the all-over-the-body cutaneous manifestation of pseudomonas infection in sepsis patients. Patients who suffer from severe illnesses. Immune deficiencies commonly increase the chance of acquiring EG. Our patient had a history of measles, which led to neutropenia before developing EG. The management of ecthyma gangrenosum requires early identification and antimicrobial treatment. Conclusion:We describe a measles patient who developed coagulase-negative Staphylococcus ecthyma gangrenosum and had good results from both surgical debridement and systemic antibiotics. Our case serves as an example of the uncommon presentation of ecthyma gangrenosum. This example emphasizes the value of an early diagnosis and vigorous antimicrobial therapy in cases where ecthyma gangrenosum is clinically suspected.

show abstract

Section: Discussionmentioning

confidence: 77%

“…3 This illness often affects the extremities, gluteal, and perineal areas, and it has been linked to fatal septicaemic infections and high mortality. 4 We report a case of ecthyma gangrenosum in an infant after a measles infection.…”

Section: Introductionmentioning

confidence: 96%

An Infant with Measles Developed Ecthyma Gangrenosum Caused by Coagulase-Negative Staphylococcus: A Rare Case Report from Somalia

Ali,

Mohamed,

Hirsi

et al. 2023

IMCRJ

View full text Add to dashboard Cite

show abstract

“…Skin manifestations associated with P. aeruginosa infections may range from less severe localized forms of primary skin infections including Green Nail Syndrome, Interdigital Infections, and hot tub Folliculitis to more severe forms occurring in immunocompromised patients such as Ecthyma Gangrenosum and subcutaneous nodules usually occurring with bloodstream infections and also necrotizing skin and soft tissue infections occurring in diabetic, alcoholic and immunocompromised patients (Spernovasilis et al, 2021). P. aeruginosa plays an important role as a pathogen that extends beyond human infections; it also poses a significant threat to animals, including pets and livestock, with skin infections being a notable concern (Singh et al, 2005). In animals, P. aeruginosa can cause a range of dermatological conditions, including wound infections, hot spots, and otitis infections (de Sousa et al, 2023;Elfadadny et al, 2023b).…”

Section: Pseudomonas Aeruginosa and Skin Infectionsmentioning

confidence: 99%

Antimicrobial resistance of Pseudomonas aeruginosa: navigating clinical impacts, current resistance trends, and innovations in breaking therapies

Elfadadny,

Ragab,

AlHarbi

et al. 2024

Front. Microbiol.

View full text Add to dashboard Cite

Pseudomonas aeruginosa, a Gram-negative bacterium, is recognized for its adaptability and opportunistic nature. It poses a substantial challenge in clinical settings due to its complicated antibiotic resistance mechanisms, biofilm formation, and capacity for persistent infections in both animal and human hosts. Recent studies revealed a potential zoonotic transmission of P. aeruginosa between animals, the environment, and human populations which highlights awareness of this microbe. Implementation of the One Health approach, which underscores the connection between human, animal, and environmental health, we aim to offer a comprehensive perspective on the current landscape of P. aeruginosa management. This review presents innovative strategies designed to counteract P. aeruginosa infections. Traditional antibiotics, while effective in many cases, are increasingly compromised by the development of multidrug-resistant strains. Non-antibiotic avenues, such as quorum sensing inhibition, phage therapy, and nanoparticle-based treatments, are emerging as promising alternatives. However, their clinical application encounters obstacles like cost, side effects, and safety concerns. Effectively addressing P. aeruginosa infections necessitates persistent research efforts, advancements in clinical development, and a comprehension of host-pathogen interactions to deal with this resilient pathogen.

show abstract

Newborn With Unexpected Skin Lesions

et al. 2014

View full text Add to dashboard Cite

A 25-day-old newborn was admitted to our hospital with a diagnosis of bronchiolitis. During admission, the infant developed violaceous skin lesions with edema in inguinal and axillary regions (Figure). Lesions became ulcerated within 3 to 4 days, with infarcted necrotic areas. Blood tests showed leukopenia (white blood cell count, 2460/μL) with neutropenia (neutrophil count, 220/μL) (to convert both to ×10 9 per liter, multiply by 0.001). The lesions were biopsied and samples were sent for cultures and histopathological analysis. Intravenous floxacillin was started, followed by surgical debridement due to progression of the major lesions.His mother was addicted to drugs, she had a known hepatitis C virus infection, and the pregnancy was unsupervised. Thirteen days before delivery, she visited the emergency department with flulike symptoms. Routine infectious screening revealed negative serology for syphilis, hepatitis B virus, and human immunodeficiency virus (HIV) types 1 and 2 by enzyme-linked immunosorbent assay (ELISA). The infant was born at 40 weeks' gestation by forceps delivery.

show abstract

Ecthyma Gangrenosum: A Rare Cutaneous Manifestation Caused by Pseudomonas Aeruginosa Without Bacteraemia in a Leukaemic Patient- A Case Report

Cited by 24 publications

References 6 publications

An Infant with Measles Developed Ecthyma Gangrenosum Caused by Coagulase-Negative Staphylococcus: A Rare Case Report from Somalia

An Infant with Measles Developed Ecthyma Gangrenosum Caused by Coagulase-Negative Staphylococcus: A Rare Case Report from Somalia

Antimicrobial resistance of Pseudomonas aeruginosa: navigating clinical impacts, current resistance trends, and innovations in breaking therapies

Newborn With Unexpected Skin Lesions

Contact Info

Product

Resources

About