Ecthyma gangrenosum as an initial manifestation of acute lymphoblastic leukemia

Extensive perineal ecthyma gangrenosum in leukocyte adhesion deficiency type 1 associated with Staphylococcus hominis bacteremia

“…Although granulocyte transfusion is not the standard treatment for LAD, granulocyte transfusion in disorders of neutrophil function has been successful as an adjunctive therapy in refractory or lifethreatening infections, including EG associated with LAD. [7][8][9] Children who received early initiation (<1 month from the onset of infection)…”

“…7,10 This case highlights the need for further research on the role of granulocyte transfusion in neutrophilic disorders as the available data is limited to few case reports. [7][8][9] Hematopoietic stem cell transplantation, the definitive treatment, if done at a median age of 9 months (2 months-14 years), has been associated with an overall survival rate of 75%. 11 Non-availability of sibling donors should not be a limiting factor as haploidentical stem cell transplantation has a similar survival rate.…”