Ectomesenchymal chondromyxoid tumor of the tongue: insights on histogenesis

Ectomesenchymal chondromyxoid tumor with a significant proliferative index: A case report

“…Although the WHO describes the ECT as a rare benign mesenchymal tumor with a myoepithelial cell-like phenotype, 1,10,11 there is unanimous agreement that this tumor arises from neural crest cells. 2,5,8,[12][13][14][15][16][17] The clinical features of the present case are consistent with those reported in the literature, which describe the ECT as an asymptomatic lesion that usually measures less than 2 cm in diameter, is located on the back of the tongue and affects patients at a mean age of 34 years. 1,2,5,6,8,11,12,18,19 Histologically, the present case meets the morphological criteria for the diagnosis of ECT.…”

Ectomesenchymal Chondromyxoid Tumor: A Series of Seven Cases and Review of the Literature

“…This also may explain the tendency of this tumor to develop on this particular area of the oral cavity. Yoshioka et al [12] found that ECTderived cells were morphologically similar to neuronal cells and might present characteristics similar to undifferentiated embryonic stem cells, with potential for multilineage differentiation. Although ECT has a distinct clinical location on the anterior tongue that might help in establishing the diagnosis, its histopathological features (myxoid and/or chondroid stroma, pleomorphism, nuclear inclusions, and amphophilic cytoplasm) can overlap with that seen in other soft tissue and minor salivary gland neoplasms.…”

Nodular lesion in the buccal mucosa

“…ECT was first described in 1995, 1 with 52 cases reported in the English-language literature: 50 cases were in the tongue; 1 was in the hard palate; and 1 was in the buccal mucosa. [1][2][3][4][5][6][7][8] The cases described in the literature reported that ECT most commonly affects adults in the third to sixth decades of life. Clinically, ECT presents as a slow-growing, painless, firm, wellcircumscribed, submucosal nodule, covered by normal mucosa, that appears to involve only the oral cavity and usually is located on the anterior dorsum of the tongue.…”