Ectopic ACTH Secretion in a Child With Metastatic Ewing's Sarcoma: A Case Report

Ruscio, Valentina Di; Baldo, Giada Del; Pasquale, Maria Debora De; Vito, Rita De; Miele, Evelina; Colafati, Giovanna Stefania; Deodati, Annalisa; Ioris, Maria Antonietta De; Tornesello, Assunta; Milano, Giuseppe Maria; Mastronuzzi, Angela

doi:10.3389/fonc.2020.00574

Cited by 7 publications

(7 citation statements)

References 29 publications

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“…The fourth case was of a ten-year-old boy from Italy with Cushing's syndrome caused by ectopic ACTH production from a metastatic ES tumor of the right ischio-pubic rami with multiple secondaries who was managed with chemotherapy but succumbed to the illness (9). The present case assumes significance in view of being the 1 st case of ES of the humerus with ectopic ACTH.…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 75%

“…Ectopic ACTH caused by sarcomatous tumors is still rarer (4,5). As far as we were able to determine, only four patients with ACTH-dependent Cushing's syndrome caused by ES have been reported to date (6,7,8,9). We report the first case of ectopic ACTH with ES arising from the humerus.…”

Section: Introductionmentioning

confidence: 83%

“…4 , 5 As far as we were able to determine, only 4 patients with ACTH-dependent Cushing syndrome caused by ES have been reported to date. 6 , 7 , 8 , 9 …”

Section: Introductionmentioning

confidence: 99%

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Rapidly Fatal Ectopic Adrenocorticotropic Hormone Syndrome in a 9-Year-Old Girl With Ewing Sarcoma

Varghese

Mythili

Reddy

et al. 2022

AACE Clinical Case Reports

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 75%

Section: Introductionmentioning

confidence: 83%

See 1 more Smart Citation

Rapidly Fatal Ectopic Adrenocorticotropic Hormone Syndrome in a 9-Year-Old Girl With Ewing Sarcoma

Varghese

Mythili

Reddy

et al. 2022

AACE Clinical Case Reports

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“…On the other hand, there are those that believe its lineage arises from neural crest cells, which one would expect would make it more predisposed to neurologic paraneoplastic syndromes [7]. The few cases of paraneoplastic syndrome with Ewing sarcomas that have been reported have been endocrinopathies involving Cushing's syndrome and ectopic ACTh release [8][9][10]. This case is believed to be the first to have an association between Ewing sarcoma and Guillain-Barre Syndrome.…”

Section: Case Reportmentioning

confidence: 88%

Guillain-Barre Syndrome as a Paraneoplastic Syndrome from Ewing Sarcoma

MH¹,

Le²,

CW³

2021

sarcomaresint

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Background: Paraneoplastic syndromes have been associated with certain malignancies, classically with small cell lung cancer. However, there have been case reports of solid tumors that have been associated with paraneoplastic syndromes as well. This is believed to be the first case that details a young man with Ewing sarcoma who developed Guillain-Barre Syndrome in the form of a paraneoplastic syndrome. Case Presentation: A 23-year-old man with localized Ewing sarcoma presented to the hospital with weakness. He was initially treated with interval compressed chemotherapy and radiation, but developed recurrence and underwent hemipelvectomy. He had chronic numbness of his extremities from vincristine that felt acutely worsened over several days prior to admission. Additionally, he was now having difficulty grasping objects and walking. His exam was notable for mildly decreased strength in his lower extremities but preserved in his upper extremities along with intact extraocular movements. The following morning he was unable to move and lost all sensation in his left lower extremity along with new dysphagia. Urgent work-up revealed a normal MRI brain, MRI spine with enhancement of cauda equina nerve roots around the conus, and a lumbar puncture with cytoalbuminologic dissociation. Ultimately was diagnosed with presumed Guillain-Barre Syndrome and treated with IVIG. Conclusion: Guillain-Barre is a rare but serious syndrome that needs to be recognized quickly given its high mortality and morbidity rate and necessity of quick intervention. It is imperative for clinicians to maintain a high degree of clinical suspicion as a manifestation of paraneoplastic syndrome from malignancies.

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“…In the present study, we evaluated the expression of 6 important miRNAs (miR-21-5p, miR-199a-5p, miR155-5p, miR-34a-5p, miR-145-5p, and miR-218-5p) selected based on results of several previous studies complete database search 19 , 20 . Some of these miRNAs are also found to be associated with HR-HPV infection in cervical pre-cancer and cancer 21 , 22 .…”

Section: Discussionmentioning

confidence: 99%

Urine miRNA signature as a potential non-invasive diagnostic and prognostic biomarker in cervical cancer

Aftab

Poojary

Seshan

et al. 2021

Sci Rep

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MicroRNAs as cancer biomarkers in serum, plasma, and other body fluids are often used but analysis of miRNA in urine is limited. We investigated the expression of selected miRNAs in the paired urine, serum, cervical scrape, and tumor tissue specimens from the women with cervical precancer and cancer with a view to identify if urine miRNAs could be used as reliable non-invasive biomarkers for an early diagnosis and prognosis of cervical cancer. Expression of three oncomiRs (miR-21, miR-199a, and miR-155-5p) and three tumor suppressors (miR-34a, miR-145, and miR-218) as selected by database search in cervical pre-cancer, cancer, and normal controls including cervical cancer cell lines were analyzed using qRT-PCR. The expression of miRNAs was correlated with various clinicopathological parameters, including HPV infection and survival outcome. We observed a significant overexpression of the oncomiRs and the downregulation of tumor suppressor miRNAs. A combination of miR-145-5p, miR-218-5p, and miR-34a-5p in urine yielded 100% sensitivity and 92.8% specificity in distinguishing precancer and cancer patients from healthy controls and it well correlates with those of serum and tumor tissues. The expression of miR-34a-5p and miR-218-5p were found to be independent prognostic factors for the overall survival of cervical cancer patients. We conclude that the evaluation of the above specific miRNA expression in non-invasive urine samples may serve as a reliable biomarker for early detection and prognosis of cervical cancer.

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Ectopic ACTH Secretion in a Child With Metastatic Ewing's Sarcoma: A Case Report

Cited by 7 publications

References 29 publications

Rapidly Fatal Ectopic Adrenocorticotropic Hormone Syndrome in a 9-Year-Old Girl With Ewing Sarcoma

Rapidly Fatal Ectopic Adrenocorticotropic Hormone Syndrome in a 9-Year-Old Girl With Ewing Sarcoma

Guillain-Barre Syndrome as a Paraneoplastic Syndrome from Ewing Sarcoma

Urine miRNA signature as a potential non-invasive diagnostic and prognostic biomarker in cervical cancer

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