2022
DOI: 10.1101/2022.12.22.521568
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

Ectopic activation of the polar body extrusion pathway triggers cell fragmentation in preimplantation embryos

Abstract: Cell fragmentation occurs during physiological processes, such as apoptosis, migration, or germ cell development. Fragmentation is also commonly observed during preimplantation development of human embryos and is associated with poor implantation prognosis during Assisted Reproductive Technology (ART) procedures. Despite its biological and clinical relevance, the mechanisms leading to cell fragmentation are unclear. Light sheet microscopy imaging of mouse embryos reveals that compromised spindle anchoring, due… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2023
2023
2023
2023

Publication Types

Select...
2

Relationship

1
1

Authors

Journals

citations
Cited by 2 publications
(1 citation statement)
references
References 57 publications
0
1
0
Order By: Relevance
“…Unlike DTC fragments, however, these descendants each have reduced nuclear content but none lack a nucleus entirely. An example of mouse cells fragmenting has recently been reported in the early embryo as a consequence of ectopic activation of the polar body extrusion pathway in blastomeres 98 . The behavior of the DTC after loss of Rac pathway activity is one of rather few documented instances of cell fragmentation without cell death.…”
Section: Bifurcated Germlines Are Mispatterned With Differentiating G...mentioning
confidence: 99%
“…Unlike DTC fragments, however, these descendants each have reduced nuclear content but none lack a nucleus entirely. An example of mouse cells fragmenting has recently been reported in the early embryo as a consequence of ectopic activation of the polar body extrusion pathway in blastomeres 98 . The behavior of the DTC after loss of Rac pathway activity is one of rather few documented instances of cell fragmentation without cell death.…”
Section: Bifurcated Germlines Are Mispatterned With Differentiating G...mentioning
confidence: 99%