Ectopic extramammary Paget disease mimicking Bowen disease

Namiki, Takeshi; Iikawa, Madoka; Otsuki, Yuki; Ueno, Makiko; Yokozeki, Hiroo

doi:10.1016/j.jaad.2015.12.047

Cited by 6 publications

(4 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Histopathologically, the lesions exhibited “cleft like” acantholysis with full‐thickness atypia, mimicking acantholytic squamous cell carcinoma in situ 16 . Two additional cases of PD with similar features were reported in 2009, 17 and since that time similar findings have been reported in cases of EMPD under various descriptions, including acantholytic anaplastic EMPD, EMPD mimicking acantholytic squamous cell carcinoma in situ, and syringocystadenocarcinoma papilliferum in situ (SCACPIS)‐like change 16‐29 . In addition to the findings of these atypical cases of EMPD with full‐thickness bowenoid atypia and acantholysis, our case also notably overlaps with prior descriptions of SCACPIS, including prominent glandular formation and involvement of adnexal structures with papillations and a plasma‐cell‐rich infiltrate.…”

Section: Discussionsupporting

confidence: 58%

“…To avoid diagnostic confusion and in keeping with historical initial descriptions of the findings in our case, we suggest applying the terminology of “anaplastic EMPD” or “EMPD with anaplastic features” to cases of EMPD with findings previously described under SCACPIS‐like change in EMPD, acantholytic anaplastic EMPD, EMPD mimicking acantholytic SCCIS, and anogenital SCACPIS, including: full‐thickness bowenoid atypia, acantholysis, glandular formation, adnexal involvement, and anogenital site 16‐29 . Adoption and application of consistent terminology would help to solidify knowledge and awareness of this histopathologic variant.…”

Section: Discussionmentioning

confidence: 91%

“…Of additional interest, multiple cases of SCACPIS have been described in the anogenital region 17‐21 . Despite the variations in interpretations of findings, the aforementioned cases of EMPD and anogenital SCACPIS share similar histopathologic and clinical features—likely representing findings on a spectrum of the same entity—and are summarized in Table 1 19‐29 …”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Anogenital syringocystadenocarcinoma papilliferum in situ or anaplastic extramammary Paget disease? A unifying concept and review of the literature

Sheldon

Buckley²,

Ulman

et al. 2021

J Cutan Pathol

View full text Add to dashboard Cite

Extramammary Paget disease (EMPD) is a rare cutaneous malignancy that typically involves the genital skin and can be primary or associated with an underlying internal malignancy. The typical histopathological appearance of EMPD consists of single or small aggregates of cells with abundant pale cytoplasm and large pleomorphic nuclei, known as Paget cells, scattered throughout the epidermis. We report a case of anogenital EMPD occurring in a 53‐year‐old man with unusual histopathologic findings of marked epidermal acanthosis, acantholysis, intraepidermal glandular differentiation, and prominent plasma cell‐rich fibrovascular cores. These features were entirely confined to the epidermis and adnexa with no evidence of dermal invasion or underlying systemic disease. We review and summarize the literature for atypical features noted in EMPD and summarize similar findings previously described under a variety of descriptions including anaplastic EMPD, anogenital syringocystadenocarcinoma papilliferum in situ (SCACPIS), SCACPIS‐like changes in EMPD, and EMPD mimicking acantholytic squamous cell carcinoma in situ. We propose that these features represent a single entity and be considered under a unifying diagnosis to facilitate recognition of this entity.

show abstract

Section: Discussionsupporting

confidence: 58%

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Anogenital syringocystadenocarcinoma papilliferum in situ or anaplastic extramammary Paget disease? A unifying concept and review of the literature

Sheldon

Buckley²,

Ulman

et al. 2021

J Cutan Pathol

View full text Add to dashboard Cite

show abstract

“…In relation to the dermoscopic findings described, we must consider Bowen disease and malignant melanoma in the differential diagnosis. Only one dermoscopic sign described here, the irregular brown structures, could be more associated with E-EMPD [5].…”

Section: Case Discussionmentioning

confidence: 69%