Ectopic Fat Storage in the Pancreas, Liver, and Abdominal Fat Depots: Impact on β-Cell Function in Individuals with Impaired Glucose Metabolism

Zijl, N.J. van der; Goossens, Gijs H.; Moors, C.C.M.; Raalte, Daniël H. van; Muskiet, Marcel H.A.; Pouwels, Petra J. W.; Blaak, Ellen E.; Diamant, Michaëla

doi:10.1210/jc.2010-1722

Cited by 179 publications

(126 citation statements)

References 39 publications

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“…However, since pancreatic fat content may also be affected by age and obesity, a causal association between pancreatic fat content and glucose intolerance or beta-cell dysfunction is difficult to establish [106,[131][132][133][134][135][136]. In our analysis, using CT scan, there was a significant correlation between pancreatic fat content and BMI, but no significant difference in pancreatic fat volume between subjects with and without T2D who were matched for age, sex, and BMI [13] ( Table 1 and Figure 4).…”

Section: Pancreatic Fat Beta-cell Function and Glucose Intolerancementioning

confidence: 68%

Pancreas Volume and Fat Deposition in Diabetes and Normal Physiology: Consideration of the Interplay Between Endocrine and Exocrine Pancreas

Saisho¹

2016

Rev Diabet Stud

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■ AbstractThe pancreas is comprised of exocrine and endocrine components. Despite the fact that they are derived from a common origin in utero, these two compartments are often studied individually because of the different roles and functions of the exocrine and endocrine pancreas. Recent studies have shown that not only type 1 diabetes (T1D), but also type 2 diabetes (T2D), is characterized by a deficit in beta-cell mass, suggesting that pathological changes in the pancreas are critical events in the natural history of diabetes. In both patients with T1D and those with T2D, pancreas mass and exocrine function have been reported to be reduced. On the other hand, pancreas volume and pancreatic fat increase with obesity. Increased beta-cell mass with increasing obesity has also been observed in humans, and ectopic fat deposits in the pancreas have been reported to cause beta-cell dysfunction. Moreover, neogenesis and transdifferentiation from the exocrine to the endocrine compartment in the postnatal period are regarded as a source of newly formed beta-cells. These findings suggest that there is important interplay between the endocrine and exocrine pancreas throughout life. This review summarizes the current knowledge on physiological and pathological changes in the exocrine and endocrine pancreas (i.e., beta-cell mass), and discusses the potential mechanisms of the interplay between the two compartments in humans to understand the pathophysiology of diabetes better.

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Section: Pancreatic Fat Beta-cell Function and Glucose Intolerancementioning

confidence: 68%

Pancreas Volume and Fat Deposition in Diabetes and Normal Physiology: Consideration of the Interplay Between Endocrine and Exocrine Pancreas

Saisho¹

2016

Rev Diabet Stud

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“…Excess liver fat, and its related condition of NAFLD, have been recognized as playing an important role in the T2DM-onset mechanism [3,17]. However, pancreatic ectopic fat, which we previously defined as PS, may also impair pancreatic β-cell function.…”

Section: Discussionmentioning

confidence: 98%

“…It is clear that obesity is a major risk factor for T2DM, and it appears to drive tissue insulin resistance via ectopic fat gain, with the best-studied organ being the liver [1][2][3]. Excess liver fat, and its related condition of NAFLD, have been recognized as playing an important role in the T2DM-onset mechanism [3,17].…”

Section: Discussionmentioning

confidence: 99%

Pancreas volume reduction and metabolic effects in Japanese patients with severe obesity following laparoscopic sleeve gastrectomy

et al. 2017

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“…However, conflicting results were reported both with regard to the amount of pancreatic fat [16,17,19,21] and the association with beta cell function in humans [18][19][20][21]24]. These differences could be attributed to the various fat compartments found within the pancreas, and the variability they cause in invasive and non-invasive measurements.…”

Section: Introductionmentioning

confidence: 99%

Pancreatic adipose tissue infiltration, parenchymal steatosis and beta cell function in humans

et al. 2015

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Aims/hypothesis This study aimed to perform a comprehensive analysis of interlobular, intralobular and parenchymal pancreatic fat in order to assess their respective effects on beta cell function. Methods Fifty-six participants (normal glucose tolerance [NGT] (n=28), impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT) (n=14) and patients with type 2 diabetes (n=14)) underwent a frequent-sampling OGTT and non-invasive magnetic resonance imaging (MRI; whole-body and pancreatic) and proton magnetic resonance spectroscopy ( 1 H-MRS; liver and pancreatic fat). Total pancreatic fat was assessed by a standard 2 cm H-MRS techniques revealed an inhomogeneous distribution of interlobular and intralobular adipose tissue, which increased with decreasing glucose tolerance. mDIXON-MRI measurements provided evidence against uniform steatosis, revealing regions of parenchymal tissue void of lipid accumulation in all participants. Total (r=0.385, p<0.01) and intralobular pancreas adipose tissue infiltration (r=0.310, p< 0.05) positively associated with age, but not with fasting or 2 h glucose levels, BMI or visceral fat content (all p>0.5). Furthermore, no associations were found between total and intralobular pancreatic adipose tissue infiltration and insulin secretion or beta cell function within NGT, IFG/IGT or patients with type 2 diabetes (all p>0.2). Conclusions/interpretation The pancreas does not appear to be another target organ for abnormal endocrine function because of ectopic parenchymal fat storage. No relationship was found between pancreatic adipose tissue infiltration and beta cell function, regardless of glucose tolerance status.

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Ectopic Fat Storage in the Pancreas, Liver, and Abdominal Fat Depots: Impact on β-Cell Function in Individuals with Impaired Glucose Metabolism

Abstract: PFC was increased in individuals with IFG and/or IGT, without a direct relation with β-cell function.

Cited by 179 publications

References 39 publications

Pancreas Volume and Fat Deposition in Diabetes and Normal Physiology: Consideration of the Interplay Between Endocrine and Exocrine Pancreas

Pancreas Volume and Fat Deposition in Diabetes and Normal Physiology: Consideration of the Interplay Between Endocrine and Exocrine Pancreas

Pancreas volume reduction and metabolic effects in Japanese patients with severe obesity following laparoscopic sleeve gastrectomy

Pancreatic adipose tissue infiltration, parenchymal steatosis and beta cell function in humans

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