Ectopic pheochromocytoma arising in the spermatic cord 5 years after removal of bilateral carotid body tumors and adrenal pheochromocytomas

Abe, Takashige; Matsuda, Hiroyuki; Shindo, Junichi; Nonomura, Katsuya; Koyanagi, Tomohiko

doi:10.1046/j.1442-2042.2000.00143.x

Cited by 22 publications

(16 citation statements)

References 8 publications

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“…The importance of nodules of EACT in the groin should not be overstated. There have been reported cases of phaeochromocytoma developing in the groin [22], and of Cushing's syndrome associated with ectopic adrenal tissue [23], but these are very rare. In agreement with other authors, we consider it reasonable to excise a nodule of EACT found incidentally, but not to risk injuring spermatic cord structures by systematically searching for it.…”

Section: Discussionmentioning

confidence: 99%

Ectopic adrenocortical tissue found at groin exploration in children: incidence in relation to diagnosis, age and sex

2005

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and the incidence in different groups compared. RESULTSOf 935 groin explorations, EACT was identified in 25 (2.7%); there were no cases in girls. The incidence was 0.7% at inguinal herniotomy (IH), 4.1% at ligation of the patent processus vaginalis for communicating hydrocele ( P = 0.03 vs IH), and 3.3% at exploration for undescended testes ( P = 0.02 vs IH). In boys with undescended testes the incidence of EACT was similar in different age groups (0-7 years, 3.3%; 8-15 years 3.2%, P = 0.96). CONCLUSIONSThe overall incidence of EACT at groin exploration was 2.7%, with none detected in girls. There was no evidence of involution of EACT with increasing age. The incidence of EACT varied with the underlying diagnosis, but the reason for this is unknown.

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Section: Discussionmentioning

confidence: 99%

Ectopic adrenocortical tissue found at groin exploration in children: incidence in relation to diagnosis, age and sex

2005

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“…Moreover, it is not clinically significant and also not associated with endocrine abnormalities. Nevertheless, the occurrence of pheochromocytoma and Cushing's syndrome associated with aberrant adrenal tissue has been reported [11] [12]. The patient in this case had a history of hypertension since early 40's.…”

Section: Discussionmentioning

confidence: 90%

Aberrant Adrenocortical Tissue Associated with Resected Lipoma of Spermatic Cord in an Adult

Takeuchi¹,

Okuya²,

Kato³

et al. 2014

OJU

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Aberrant adrenocortical tissue in spermatic cord is rare in adult population. We report an unusual case of a 52-year-old male patient with an aberrant adrenocortical tissue which is incidentally resected within lipoma of spermatic cord and identified on microscopic examination. Although he was diagnosed with right inguinal hernia, there was no significant hernia orifice intraoperatively. When the 2nd operation by anterior open approach was undergone, there was a fat-like tissue adhered to the spermatic cord. It was removed and the histopathological finding first revealed aberrant adrenocortical tissue in the resected lipoma of spermatic cord (Figure 1). This abnormal tissue is usually found incidentally during inguinal operation. In general, most of the aberrant adrenal tissue becomes atrophic by adult life. Moreover, it is not clinically significant and also not associated with endocrine abnormalities.

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“…Thus far, these paragangliomas have been described in middle-aged men, none of whom has had genetic testing, although one patient clearly had evidence of multiple tumours, for which we would strongly recommend systematic candidate gene mutation analysis [11]. Until about 10 years ago, pheochromocytomas and paragangliomas were known to occur in the context of various tumour syndromes, including multiple endocrine neoplasia type 2 (MEN 2), VHL disease, and NF1.…”

Section: Discussionmentioning

confidence: 99%

A non-catecholamine-producing sympathetic paraganglioma of the spermatic cord: the importance of performing candidate gene mutation analysis

et al. 2010

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BackgroundCatecholamine-producing tumours are called pheochromocytomas when they are located in the adrenal gland and sympathetic paragangliomas when they are located elsewhere in the abdomen. Rarely these tumours do not produce catecholamines and even more rarely they arise in the spermatic cord. Over the past decade, systematic mutation analysis of apparently sporadic cases of pheochromocytomas and paragangliomas has elucidated the frequent presence of germ line mutations in one of five candidate genes, including RET, VHL, SDHB, SDHC, and SDHD.Clinical history and methodsWe describe a 45-year-old man with a non catecholamine-producing paraganglioma of the spermatic cord. We performed SDHB immunohistochemistry and performed mutation analysis of the SDHB, SDHC, and SDHD genes.ResultsThere was no staining of tumour cells with SDHB immunohistochemistry, indicative of an SDH mutation. Mutation analysis demonstrated a germ line SDHD mutation (p.Val147Met).ConclusionsSystematic mutation analysis is required in paraganglioma patients for the detection of germ line mutations. This should be preceded by SDHB immunohistochemistry to limit the number of genes to be tested.

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Ectopic pheochromocytoma arising in the spermatic cord 5 years after removal of bilateral carotid body tumors and adrenal pheochromocytomas

Cited by 22 publications

References 8 publications

Ectopic adrenocortical tissue found at groin exploration in children: incidence in relation to diagnosis, age and sex

Ectopic adrenocortical tissue found at groin exploration in children: incidence in relation to diagnosis, age and sex

Aberrant Adrenocortical Tissue Associated with Resected Lipoma of Spermatic Cord in an Adult

A non-catecholamine-producing sympathetic paraganglioma of the spermatic cord: the importance of performing candidate gene mutation analysis

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