Ectopic primary olfactory neuroblastoma of the nasopharynx: A case report and review of the literature

Caldwell, Nicholas J.; Sato, T. Shawn

doi:10.1016/j.radcr.2019.05.031

Cited by 8 publications

(11 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Imaging of ONBs can typically reveal a mass of "dumbbell shape" crossing the cribriform plate or cysts at the junction of the tumor and brain tissue. [3,4] e reported patient's CT did not demonstrate this "dumbbell" imaging pattern, though MRI has not yet been obtained to definitively determine the extent of anterior cranial fossa involvement. e diagnostic protocol of ONB begins with a histologically confirmed positive biopsy usually, followed by classification.…”

Section: Discussionmentioning

confidence: 98%

Mixed olfactory neuroblastoma and neuroendocrine carcinoma: An unusual case report and literature review

Lao

Thompson

Evans

et al. 2020

Surgical Neurology International

View full text Add to dashboard Cite

Background: The aim of the study was to present a case of mixed olfactory neuroblastoma (ONB) and carcinoma, an extremely rare tumor with only a few cases in the published literature. Case Description: An otherwise healthy 27-year-old male presented with sinus complaints, headache, and unilateral eye discharge. Imaging and endoscopy revealed a mass presumed to represent a juvenile nasopharyngeal angiofibroma. Unexpectedly, the final pathology report revealed high grade mixed ONB and carcinoma. This tumor is the sixth and youngest documented patient with mixed ONB and carcinoma. Conclusion: Physicians should remain vigilant for the possibility of malignancy in their approach to nasal cavity masses, even in young otherwise healthy patients. Careful review of the immunohistopathology should also be taken, as mixed olfactory tumors such as these are aggressive, rare entities that require multidisciplinary oncologic care.

show abstract

Section: Discussionmentioning

confidence: 98%

Mixed olfactory neuroblastoma and neuroendocrine carcinoma: An unusual case report and literature review

Lao

Thompson

Evans

et al. 2020

Surgical Neurology International

View full text Add to dashboard Cite

show abstract

“…Imaging modalities such as CT and MRI are considered as gold standard imaging modality to diagnose ONB. [ 9 18 ] ONB appears on contrast-enhanced CT as homogeneous soft-tissue mass with moderate and uniform enhancement. [ 19 ] CT with no contrast is used to assess the presence of speckled calcification and bone erosion of the cribriform plate, lamina papyracea, and fovea ethmoidalis.…”

Section: Discussionmentioning

confidence: 99%

“…MRI uses pre- and post-contrast image after gadolinium injection, where it appears as hypointense areas compared to gray matter on T1-weighted image and hyperintense areas on the T2-weighted image. [ 9 19 ] The classic and characteristic feature of ONB that appears in imaging studies is its “dumbbell-shaped” mass extending across the cribriform plate. [ 20 21 ]…”

Section: Discussionmentioning

confidence: 99%

“…[ 8 ] Reported ectopic ONB sites of origin include the anterior ethmoids, sphenoid sinus, maxillary sinus, pituitary gland, nasopharynx, sellar region, nasal cavity inferior meatus, and noise floor. [ 9 ] The management of ONB usually follows a multidisciplinary that includes surgery, chemotherapy, and radiotherapy (RT). Cases treated with combination of surgery and RT have shown superior survival rates and life expectancy.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Olfactory Neuroblastoma Managed with Endoscopic Sinus Surgery

Al-Osaimi

Hameed

Alsufyani

et al. 2021

Journal of Pharmacy and Bioallied Sciences

View full text Add to dashboard Cite

Olfactory neuroblastoma (ONB) or esthesioneuroblastoma is a rare malignancy of the nose and paranasal sinuses that originates from the upper nasal vault. We report a rare case of ONB in a 27-year-old female patient with a 2-year history of nasal obstruction, sneezing, nasal discharge, and left eye protrusion. The patient was successfully treated with endoscopic sinus surgery and adjuvant radiotherapy (RT) with 5-year follow-up duration. Studying ONB cases is of great importance due to its rare occurrence, and the lack of literature regarding its management often creates a dilemma leading to nonstandardized treatment methods. Prolonged surveillance is essential due to its late recurrence and endoscopic resection followed by adjuvant RT, which may be a feasible and effective treatment. There is no single case of ONB published yet in Saudi Arabia, and to our knowledge, this is the first case report.

show abstract

“…basal cells of the olfactory epithelium 3,4,65 . Furthermore, the etiology of aberrant ectopic cases has yet to be determined.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Ectopic Olfactory Neuroblastoma: Systematic Review of a Rare Clinical Entity among Sinonasal Tumors

Lui

Badash

Tang

et al. 2022

J Neurol Surg B Skull Base

View full text Add to dashboard Cite

Objectives: Ectopic olfactory neuroblastoma is an uncommon manifestation of an already rare neoplasm. We aimed to systematically review the literature for cases of ectopic olfactory neuroblastoma to better characterize this rare disease entity and to present two new case reports. Methods: A search of the PubMed and Embase databases was conducted according to PRISMA guidelines to identify English-language articles reporting cases of ectopic olfactory neuroblastoma, published from 1955 through November 2021. Results: 66 cases of ectopic olfactory neuroblastoma were identified in 62 articles including the current review. Ectopic olfactory neuroblastoma arose in a wide age range (2-89 years) without significant sex predilection. It occurred most commonly in the ethmoid (25%), maxillary (25%), and sphenoid (16%) sinuses. 73% of cases presented with low Hyams grade (I-II). The most common symptoms were nasal obstruction (32%) and epistaxis (32%). Paraneoplastic syndromes were observed in 27% of patients. The most common treatment was surgical resection followed by adjuvant radiotherapy. Overall, 76% of all patients were disease-free at the time of last follow-up. Locoregional recurrences and distant metastases were found in 19% and 5% of cases, respectively. Conclusions: This systematic review describes previously reported cases of ectopic olfactory neuroblastoma, a disease entity with poorly understood characteristics. Physicians should consider olfactory neuroblastoma in the differential diagnosis for sinonasal masses, as their ectopic presentation may present considerable diagnostic and therapeutic difficulties. Patients with olfactory neuroblastoma may benefit from long-term follow-up and routine endoscopic examinations for surveillance of ectopic recurrences.

show abstract

Ectopic primary olfactory neuroblastoma of the nasopharynx: A case report and review of the literature

Cited by 8 publications

References 32 publications

Mixed olfactory neuroblastoma and neuroendocrine carcinoma: An unusual case report and literature review

Mixed olfactory neuroblastoma and neuroendocrine carcinoma: An unusual case report and literature review

Olfactory Neuroblastoma Managed with Endoscopic Sinus Surgery

Ectopic Olfactory Neuroblastoma: Systematic Review of a Rare Clinical Entity among Sinonasal Tumors

Contact Info

Product

Resources

About