Ectopic Production of Human Chorionic Gonadotrophin by Human Breast Tumours

Sheth, Nandini A.; Saruiya, J N; Ranadive, K J; Sheth, A. R.

doi:10.1038/bjc.1974.236

Cited by 47 publications

(16 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It may be of interest that RIA of a hCG carried out at the same sensitivity level as for hPL did not reveal fi hCG in sera of patients with fibroadenoma of breast, and confirmed our earlier observations (Sheth et al, 1974). Greater secretion of hPL than hCG by fibroadenomas of breast is noteworthy.…”

supporting

confidence: 87%

Detection of human placental lactogen in sera and tumours of patients with fibroadenoma of breast

Sheth¹,

Adil²,

Suraiya³

et al. 1981

Br J Cancer

Self Cite

View full text Add to dashboard Cite

supporting

confidence: 87%

Detection of human placental lactogen in sera and tumours of patients with fibroadenoma of breast

Sheth¹,

Adil²,

Suraiya³

et al. 1981

Br J Cancer

Self Cite

View full text Add to dashboard Cite

“…[1][2][3][4] Additionally, isolated carcinoma cells that are reactive immunohistologically for hCG can be found in 5% to 21% of ordinary infiltrating ductal carcinomas that do not exhibit choriocarcinomatous features. 5 The presence of occasional nonchoriocarcinomatous cells that are immunoreactive to hCG does not have any prognostic significance.…”

mentioning

confidence: 99%

Carcinoma of the Breast With Choriocarcinomatous Features

Mohammadi

Rosa²

2011

Archives of Pathology &Amp; Laboratory Medicine

View full text Add to dashboard Cite

Choriocarcinomatous differentiation has been described in tumors arising from many organs including lung, rectum, colon, stomach, bladder, and rarely breast. Mammary carcinoma with choriocarcinomatous features is a rare variant of breast metaplastic carcinoma characterized by malignant cells morphologically resembling choriocarcinoma cells in which reactivity with human placental lactogen and human chorionic gonadotropin can be demonstrated by immunohistochemistry. The characteristic syncytiotrophoblast-like giant cells seen in these neoplasms are more commonly associated with moderately to poorly differentiated carcinomas with or without a clear-cut mesenchymal component. Most of the reported cases have behaved very aggressively. The reason for this poor prognosis remains unclear. Because of the small number of cases, special treatment protocols have not been developed and these patients are treated surgically and with the standard chemotherapeutic agents available for other types of carcinoma of the breast. Pathologically, these tumors must be distinguished from metastatic choriocarcinoma to the breast.

show abstract

“…LH, FSH, and TSH are produced in the anterior pituitary, whereas chorionic gonadotropin is synthesized in the developing placenta. Thus, it is significant that the isolated ␣-or ␤-subunits are also synthesized by a variety of tumors (1)(2)(3)(4)(5) and tumor-derived cell lines (6 -17). The free subunits are secreted by cell lines established from both trophoblastic (e.g.…”

mentioning

confidence: 99%

Mechanism of Gonadotropin Gene Expression

Xiong

Tapprich

Cox

2002

Journal of Biological Chemistry

View full text Add to dashboard Cite

Regulation of the glycoprotein hormone ␣-subunit (GPH␣) gene has been studied extensively in pituitary and placental cell lines, but little is known of the transcriptional regulators important for its ectopic expression. To investigate the molecular basis for ectopic expression, it was critical to define cis-regulatory elements and their cognate trans-acting factors that modulate promoter activity in epithelial cell types that do not normally express GPH. DNA-mediated transient expression of promoter-reporter constructs was used to identify a novel negative regulatory element located at the GPH␣ gene transcription start site. Truncation or site-directed mutagenesis of this element produced up to a 10-fold increase in promoter activity. Electrophoretic mobility shift analysis detected a protein that binds specifically to a DNA motif encompassing the cap site. Based on competitive DNA binding studies with mutated oligonucleotides, it was determined that bases from ؊5 to ؊2 and ؉4 to ؉11 are critical for protein binding. The DNA sequence flanking the transcription start site from ؊9 to ؉11 is an imperfect palindrome; consequently, this motif is referred to as the cap site diad element (CSDE) and the cognate factor as the cap site-binding protein (CSBP). CSBP activity was present at different levels in nuclear extracts prepared from a variety of cell types. Significantly, the ratio of activities exhibited by the GPH␣ promoter with a mutated CSDE compared with the promoter with a wild-type CSDE was dependent on the transfected cell line and its content of CSBP. These results indicate that a negative regulatory element centered at the GPH␣ gene cap site and its cognate DNA-binding protein make a significant contribution to the production of ␣-subunit in a variety of tumor tissues. A detailed understanding of this cis/trans pair may further suggest a mechanism to explain, at least in part, how this gene becomes activated in nonendocrine tumors.

show abstract

Ectopic Production of Human Chorionic Gonadotrophin by Human Breast Tumours

Cited by 47 publications

References 14 publications

Detection of human placental lactogen in sera and tumours of patients with fibroadenoma of breast

Detection of human placental lactogen in sera and tumours of patients with fibroadenoma of breast

Carcinoma of the Breast With Choriocarcinomatous Features

Mechanism of Gonadotropin Gene Expression

Contact Info

Product

Resources

About