Ectopic prostatic tissue in the spleen

Vogel, Ulrich; Negri, Giovanni; Bültmann, B.

doi:10.1007/bf00199516

“…Although different subsets of AD phenotypic traits are reproduced in these transgenic models, none of them recapitulate all features typical of AD. The anti-NGF mice described here represent a comprehensive transgenic model for AD, displaying a full complement of phenotypic hallmarks of the disease, including (26) an AD-linked muscular deficit defined as inclusion body myositis (IBM) (42). Previously described heterozygous NGF knockout mice (ngf ϩ͞Ϫ) showed The analysis was performed on six anti-NGF mice and six transgenic controls with the exception of 1-month-old mice, where the study was performed on three animals per experimental group.…”

Section: Discussionmentioning

confidence: 99%

Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice

Capsoni

¹

,

Ugolini

²

,

Comparini

³

et al. 2000

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Neurotrophin nerve growth factor (NGF) has been suggested to be involved in age-related neurodegenerative diseases, but no transgenic model is currently available to study this concept. We have obtained In this paper, we analyze the phenotype of aged anti-NGF transgenic mice and demonstrate that these mice acquire an age-dependent neurodegenerative pathology including amyloid plaques, insoluble and hyperphosphorylated , and neurofibrillary tangles in cortical and hippocampal neurons. Aged anti-NGF mice also display extensive neuronal loss throughout the cortex, cholinergic deficit in the basal forebrain, and behavioral deficits. The overall picture is strikingly reminiscent of human Alzheimer's disease. Aged anti-NGF mice represent, to our knowledge, the most comprehensive animal model for this severe neurodegenerative disease. Also, these results demonstrate that, in mice, a deficit in the signaling and͞or transport of NGF leads to neurodegeneration.

show abstract

“…Although different subsets of AD phenotypic traits are reproduced in these transgenic models, none of them recapitulate all features typical of AD. The anti-NGF mice described here represent a comprehensive transgenic model for AD, displaying a full complement of phenotypic hallmarks of the disease, including (26) an AD-linked muscular deficit defined as inclusion body myositis (IBM) (42). Previously described heterozygous NGF knockout mice (ngf ϩ͞Ϫ) showed The analysis was performed on six anti-NGF mice and six transgenic controls with the exception of 1-month-old mice, where the study was performed on three animals per experimental group.…”

Section: Discussionmentioning

confidence: 99%

Alzheimer-like neurodegeneration in aged anti-nerve growth factor transgenic mice

Capsoni¹,

Ugolini²,

Comparini³

et al. 2000

Neurobiology of Aging

View full text Add to dashboard Cite

“…Ectopic prostatic tissue is a relatively uncommon or underreported entity that is most commonly encountered in the lower male genitourinary tract, 1–16 and occasionally in the female genitourinary tract 17–23 . Other sites outside these regions have been described, including the anal canal, 24 pericolic fat, 25 retroperitoneum, 26 and spleen 27 . Multiple cases of hyperplasia in ectopic prostatic tissue causing obstructive symptoms have been described 28–31 .…”

Section: Introductionmentioning

confidence: 99%