Ectopic soft tissue calcium deposition following liver transplantation

Muñoz, Santiago J.; Nagelberg, Steven B.; Green, Paul; J, Angstadt; Yang, Shuin L.; Jarrell, Bruce E.; Maddrey, Willis C.

doi:10.1002/hep.1840080307

Cited by 47 publications

(24 citation statements)

References 22 publications

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“…Pulmonary calcification has been seen with disordered calcium deposition and/or highdose calcium administration. 7 Epstein-Barr virusassociated posttransplantation lymphoproliferative disorder is associated with airway obstruction caused by changes in the tonsillar and epiglottic areas, especially in pediatric patients.…”

Section: Pulmonarymentioning

confidence: 99%

Case presentation: Catastrophic decrease in measured oxygen saturation associated with venoveno bypass during liver transplantation

Cohen

1999

Liver Transpl

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Section: Pulmonarymentioning

confidence: 99%

Case presentation: Catastrophic decrease in measured oxygen saturation associated with venoveno bypass during liver transplantation

Cohen

1999

Liver Transpl

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“…Kh is incorporated in 2-5% creams or gels marketed in several countries. Kh and methoxypsoralens share similar photobiological, photochemical and phototherapeutic properties [3,5] . On the other hand, unlike psoralens, Kh does not induce skin phototoxicity (erythema) and hyperpigmentation of healthy skin after UVA irradiation.…”

Section: 1mentioning

confidence: 99%

“…It has been used as an either topically or orally administered PCT agent, mainly for vitiligo [3,4] , but also for psoriasis [5] . Kh is incorporated in 2-5% creams or gels marketed in several countries.…”

Section: 1mentioning

confidence: 99%

“…After liver transplantation, soft tissue calcifi cations have been described in 47-84% of cases, most frequently in the lungs, blood vessels, kidneys, pancreas, liver graft, adrenal glands, colon and gastric mucosa. In contrast, cutaneous calcifi cations were rarely observed [2][3][4][5][6][7] and more often caused by extravasation of intravenous calcium solution [6] . These dystrophic calcifi cations occurred usually at the site of injection or at different localizations along the extremity receiving the intravenous catheter [6,9] .…”

mentioning

confidence: 99%

“…Three groups of calcinosis cutis have been described: (i) calcinosis with abnormalities of the calcium-phosphorus metabolism, (ii) dystrophic calcinosis associated with underlying tissular alterations, normal serum calcium and phosphorus levels, (iii) idiopathic calcinosis if there is no other associated abnormality [1,2] . After liver transplantation, soft tissue calcium deposits are observed, but calcinosis cutis was rarely described [3][4][5][6][7] . We report the case of a liver graft recipient who developed an uncommon clinical picture of calcinosis cutis, which was associated with intrahepatic calcifi cations and successfully treated with disodium etidronate.…”

mentioning

confidence: 99%

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Uncommon Localization of Calcinosis Cutis after Liver Transplantation

Néau-Cransac¹,

Lepreux²,

Labrèze

et al. 2005

Dermatology

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Hepatic Transplantation

2001

Diseases of the Liver and Biliary System

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SummaryThis report reviews experience with 97 patients given liver transplants. We regard our survival statistics as unsatisfactory, but feel they should encourage further work since 22 patients have survived at least one year with a maximum survival of 5⅔ years. The Achilles' heel of liver transplantation is bile duct reconstruction. We presently rely upon Roux-en-Y reconstruction, or alternatively, duct-to-duct anastomosis with a T-tube stent. The prime indication for liver replacement is non-neoplastic liver disease, but a favourable malignancy for treatment may prove to be small intrahepatic duct cell carcinomas.DURING the last ten years over 200 patients have had liver replacement throughout the world. The University of Colorado Group has contributed 97 cases to this total, at a rate of 10 to 20 per year, since 1967, when the first long term survival was achieved (Starzl and Putnam, 1969). On the basis of this experience, we would like to provide a progress report regarding survival statistics, indications for operation, our present views about bile duct reconstruction, and our current programme of immunosuppression. Table 1 depicts our 97 cases. Twenty-two patients have lived for one year after operation, ten for two years and six have survived for three years. Two have passed the five years mark and both are alive now. Eighteen recipients are still alive, from three weeks to 5⅔ years postoperatively. An 18-year-old boy who is alive 5⅔ years after transplantation represents the longest survival after liver transplantation in the world. SurvivalThere have been 11 late deaths, from 12 to 41 months postoperatively, for the reasons listed in Table 2. Two late deaths were the direct consequence of failure of biliary drainage. The latest mortality was at three years, five months, and was related to an episode of haemophilus septicaemia. Recurrent cancer in patients treated for hepatoma caused three deaths after one year. This disease has also killed some of our patients earlier than this, and we therefore consider hepatoma to be a relatively poor indication for liver transplantation. However, it is not an absolute contraindication since one of our five year survivors had a hepatoma in addition to biliary atresia. Calne, and Daloze of Montreal, have also apparently cured hepatomas with liver transplantation. Biliary reconstructionWith only 22 one-year survivors, it is obvious that the operation is at present unsafe. The single most important factor in the high acute failure rate has been a multiplicity of technical misadventures, of which complications of biliary duct reconstruction lead the list. Indeed, this is now the main technical problem that we face. The different techniques we have used to restore bile drainage include choledochocholedochostomy with or without a T-tube, cholecystoduodenostomy after ligation of the graft common duct and choledochoduodenostomy. Because of continuing dissatisfaction with all of the NIH Public Access (Starzl et al., 1974).None of the commonly used methods of biliary duct rec...

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Ectopic soft tissue calcium deposition following liver transplantation

Cited by 47 publications

References 22 publications

Case presentation: Catastrophic decrease in measured oxygen saturation associated with venoveno bypass during liver transplantation

Case presentation: Catastrophic decrease in measured oxygen saturation associated with venoveno bypass during liver transplantation

Uncommon Localization of Calcinosis Cutis after Liver Transplantation

Hepatic Transplantation

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