2007
DOI: 10.1038/sj.onc.1210701
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Ectopic Tbx2 expression results in polyploidy and cisplatin resistance

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Cited by 45 publications
(49 citation statements)
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“…TBX2 may serve as a prognostic factor of breast cancer (7,9), melanoma (8), gastric cancer (10), prostate cancer (11), laryngeal squamous cell carcinoma (12), and non-small cell lung cancer (14). TBX2 is associated with resistance to therapeutic drugs such as cisplatin and doxorubicin (15,16), and TBX2 therefore may serve as a therapeutic target.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…TBX2 may serve as a prognostic factor of breast cancer (7,9), melanoma (8), gastric cancer (10), prostate cancer (11), laryngeal squamous cell carcinoma (12), and non-small cell lung cancer (14). TBX2 is associated with resistance to therapeutic drugs such as cisplatin and doxorubicin (15,16), and TBX2 therefore may serve as a therapeutic target.…”
Section: Discussionmentioning
confidence: 99%
“…Overexpression of TBX2 occurs in breast cancer (7,9), melanoma (8) pancreatic cancer (10), gastric cancer (11), prostate cancer (12), laryngeal squamous cell carcinoma (13), and non-small cell lung cancer (14). The ectopic expression of TBX2 is associated with resistance to the DNA-damaging chemotherapeutic drugs cisplatin and doxorubicin (15,16). However, the mechanism of regulation of expression and the role of TBX2 in ovarian cancer remain to be determined.…”
Section: Introductionmentioning
confidence: 99%
“…35 Primary antibodies used were as follows: rabbit polyclonal anti-TBX3 (Zymed, San Francisco, CA) and rabbit polyclonal anti-p38 (Sigma, St. Louis, MO), goat polyclonal anti-TBX2 (sc-17880), rabbit polyclonal antip53 (sc-6243), anti-p21 (sc-756), anti-p18INK4C (sc-865), anti-p16 (sc-759), and anti-p14 (sc-1063) (Santa Cruz Biotechnology, Santa Cruz, CA).…”
Section: Western Blot Analysismentioning
confidence: 99%
“…The cell cycle phase distribution was assessed by measuring DNA content by flow cytometry as described previously. 51 Western blot analyses Cells were harvested and solubilized at 4 C in RIPA buffer (150 mM NaCl, 1% Triton X-100, 0.1% SDS, 20 mM Tris pH 7.5, 1% deoxycholate and a cocktail of protease inhibitors), centrifuged at 12,000g for 20 min at 4 C and the supernatants recovered. Protein were resolved by SDS-PAGE and transferred to Hybond C (Amersham, United Kingdom).…”
Section: Plasmids and Mutagenesismentioning
confidence: 99%