Eczema-like, erythematous, infiltrated plaques: A common side effect of subcutaneous heparin therapy

Klein, Georg; Kofler, Heinz; Wolf, H.; Fritsch, Peter

doi:10.1016/s0190-9622(89)70240-1

Cited by 61 publications

(40 citation statements)

References 16 publications

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“…4,6 The skin infection in our patient was probably acquired by daily contact with a partner who died of systemic cryptococcosis. These manifestations may have polymorphous features.…”

Section: Primary Cutaneous Cryptococcosis In a Patientmentioning

confidence: 81%

Cutaneous Reactions to Azacitidine

Goldsmith¹,

Sherertz²,

Powell³

et al. 1991

Arch Dermatol

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“…4,6 The skin infection in our patient was probably acquired by daily contact with a partner who died of systemic cryptococcosis. These manifestations may have polymorphous features.…”

Section: Primary Cutaneous Cryptococcosis In a Patientmentioning

confidence: 81%

Cutaneous Reactions to Azacitidine

Goldsmith¹,

Sherertz²,

Powell³

et al. 1991

Arch Dermatol

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“…Several types if immunologically mediated reactions to heparins are known: heparin‐associated thrombocytopenia II (HAT II); immediate hypersensitivity reactions such as urticaria, asthma, and anaphylaxis; 8 generalized exanthema; 10 and a delayed‐type hypersensitivity (DTH) reaction 3,4,11,12 . DTH reactions to heparins seem to be underreported since only about 70 cases are described in the literature 13,14 .…”

mentioning

confidence: 99%

Delayed-Type Hypersensitivity and Cross-Reactivity to Heparins and Danaparoid: A Prospective Study

Grassegger

Fritsch

Reider

2001

Dermatologic Surgery

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“…Ähnliche Hautveränderungen wie bei unserer Patientin werden in der Literatur nach subkutaner Verabreichung von Heparinen beschrieben [2,8,11,18]. Erythematöse, infiltrative, schmerzhafte oder juckende Plaques entstehen meist erst nach längerdauernder Heparintherapie, sind streng an die Injektionsstellen gebunden und erinnern manchmal auch durch epidermale Beteiligung an das klinische Bild einer akuten Kontaktdermatitis.…”

unclassified

“…Man nimmt an, daß das klinische Korrelat der Injektionstiefe entspricht. Tiefe subkutane Injektionen führen zu tiefen erythematösen Schwellungen, eine eher oberflächliche Injektion zu epidermaler Beteiligung mit Vesikeln und gelegentlich auch Blasenbildung [8].…”

unclassified

Großflächige kutan-subkutane Infiltrate als Nebenwirkung von Interferon-beta-Injektion

et al. 1998

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Interferon alpha and gamma have been used to treat several hepatic, hematological and oncological diseases for years. Recently, interferon beta has been introduced as a therapeutic agent in relapsing-remitting multiple sclerosis. A 41-year-old female patient with multiple sclerosis developed non-tender, palm-sized, cutaneous-subcutaneous, reddish infiltrates at the injection sites on her thighs after 8 weeks of treatment with subcutaneous interferon beta injections. Histopathology revealed a perivascular lymphoid infiltrate of the dermis and a subtle lobular lymphoid infiltrate of the subcutis. Interferon beta therapy was discontinued for 4 weeks. With topical corticosteroids, the skin lesions resolved. When subcutaneous injections were resumed at a reduced dose, only erythema around injection sites developed without induration or pain. Slight erythema and swelling at interferon beta injection site are frequent and rare cases of cutaneous necrosis have been described. However, no reports of large, painful, cutaneous-subcutaneous infiltrates after interferon beta therapy have been published.

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Eczema-like, erythematous, infiltrated plaques: A common side effect of subcutaneous heparin therapy

Cited by 61 publications

References 16 publications

Cutaneous Reactions to Azacitidine

Cutaneous Reactions to Azacitidine

Delayed-Type Hypersensitivity and Cross-Reactivity to Heparins and Danaparoid: A Prospective Study

Großflächige kutan-subkutane Infiltrate als Nebenwirkung von Interferon-beta-Injektion

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