Eczematous dermatitis in an infantile hemangioma with minimal or arrested growth

Roncone, Krista; Kindley, K. Jade; Zlotoff, Barrett

doi:10.1111/pde.13368

Cited by 4 publications

(5 citation statements)

References 3 publications

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“…In addition, some patients may associate soft tissue hypertrophy, involving affected area that usually persists in spite of the progressive fading of the IH . An association between IH‐MAG and superimposed eczematous dermatitis has also been described …”

Section: Discussionmentioning

confidence: 99%

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Infantile hemangiomas with minimal or arrested growth: A retrospective case series

Martín

Sánchez

González

et al. 2018

Pediatric Dermatology

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Background/objectives Infantile hemangiomas (IH) with minimal or arrested growth (MAG) constitute a distinctive subset of IH based on their clinical characteristics and natural history. They are often confused with capillary malformations. Methods A retrospective observational study has been carried out in which clinical and perinatal characteristics have been evaluated in all IH‐MAG evaluated in our Dermatology Department in a 5‐year period (January 2013‐December 2017). Results A total of 14 IH‐MAG affecting 13 patients were identified (10 girls and 3 boys). All were born full term, with a mean birth weight of 3448 g for girls vs 3540 g for boys, corresponding to the 72nd percentile for both sexes. The IH‐MAG was noticed at birth in 75% of cases. It had a segmental distribution in 6 cases and focal in 8. The most common clinical features was the presence of an erythematous or reticulated background and superficial red bright papules. Lesions were located preferentially in the lower body. Doppler ultrasound showed no significant vascular abnormalities in any case. Five IH‐MAG developed ulcerations and three required treatment with propranolol. Progressive involution was observed in all cases. Conclusions In spite of being a true IH, the absence of a relationship with prematurity, the high birth weight of the newborns, the predominance on the extremities, the higher percentage of segmental lesions, and their reduced ability to proliferate suggest possible etiopathogenic differences compared with conventional IH.

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Section: Discussionmentioning

confidence: 99%

“…6 An association between IH-MAG and superimposed eczematous dermatitis has also been described. 7,10 Between 27%-38% of the segmental IH located in the extremities are IH-MAG. 11,12 Most of them have a reticular morphology, with visible and prominent surface telangiectasia.…”

Section: Discussionmentioning

confidence: 99%

Infantile hemangiomas with minimal or arrested growth: A retrospective case series

Martín

Sánchez

González

et al. 2018

Pediatric Dermatology

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“…Among the treatment options, oral propranolol was mostly used in patients with ulcers or large lesions; although the treatment duration varied, treatment responses were relatively good 9 14 . There was one case report of oral propranolol applied to non-ulcerative IH-MAGs overlying eczema leading to rapid improvement 15 . Because IH-MAGs follow the natural course of classic IHs, there are few reports related to topical treatment of IH-MAGs.…”

Section: Discussionmentioning

confidence: 99%

Infantile Hemangiomas with Minimal and Arrested Growth: Clinical Features and Treatment Outcomes with 0.5% Topical Timolol Maleate

et al. 2021

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Background A minority of infantile hemangiomas showing minimal or arrested growth (IH-MAGs) have been recognized in the literature. Nevertheless, the clinical features and treatment outcomes of IH-MAGs have not been well investigated. Objective This study aimed to understand the clinical characteristics of IH-MAGs better and their response to treatment with topical timolol maleate. Methods We retrospectively reviewed medical records and clinical images of patients with IH-MAGs. Treatment response with topical timolol was assessed in both IH-MAGs and classic infantile hemangiomas (IHs) groups. Results Of the 1,038 patients with IHs, only 31 (3.0%) were diagnosed with IH-MAGs. Lesions with non-proliferative components were more frequently distributed in the lower half of the body (61.5%) than those with proliferative components (16.7%). In 14 patients treated with topical timolol, the global assessment scale showed more significant and rapid improvement than in those with classic IHs. Conclusion Although the prevalence of IH-MAGs may be relatively low, understanding their clinical features will help in differential diagnosis. Furthermore, these type of lesions might be more responsive to topical timolol than classic IHs.

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“…2,5 The association with eczematous dermatitis has not been documented in the literature except for 1 case report that attributed the improvement of this reaction to systemic propranolol along with 2.5% hydrocortisone ointment. 7 Eczematous dermatitis association with vascular malformations like port wine stains and in nevus simplex are reported in the literature, which theorizes that the vascularity results in a vigorous inflammatory response and high cytokine release in the area, in addition to the extravasation of erythrocytes in the dermis, resembling stasis dermatitis. 8,9 This case showed the progression of eczematous dermatitis during the first few weeks of systemic propranolol initiation, although the deep hemangioma was regressing.…”

Section: Discussionmentioning

confidence: 99%

“…Regarding the associations, so far there is only 1 reported case of superimposed eczematous dermatitis associated with infantile hemangioma with minimal or arrested growth. 7 Here we describe a case of segmental mixed deep infantile hemangioma with a patch of minimal or arrested growth infantile hemangioma associated with eczematous dermatitis that progressed while the patient was receiving systemic propranolol and being managed with topical 0.03% tacrolimus ointment.…”

Section: Introductionmentioning

confidence: 98%

Eczematous dermatitis in an infantile hemangioma with minimal or arrested growth

Cited by 4 publications

References 3 publications

Infantile hemangiomas with minimal or arrested growth: A retrospective case series

Infantile hemangiomas with minimal or arrested growth: A retrospective case series

Infantile Hemangiomas with Minimal and Arrested Growth: Clinical Features and Treatment Outcomes with 0.5% Topical Timolol Maleate

Progressing eczematous dermatitis in an infantile hemangioma with minimal or arrested growth treated with tacrolimus ointment

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