SummaryA history of cardiac disease, especially atrial fibrillation, together with symptoms such as loin or abdominal pain, and accompanied by an elevated lactate dehydrogenase should prompt a computed tomography scan to exclude the diagnosis of acute renal infarction.
Case historyA 38-year-old lady was admitted to hospital with a two-day history of right loin pain and lethargy. The pain was colicky in nature and mostly experienced over the right lower abdominal quadrant and flank area. Physical examination showed a tired-looking patient with right costovertebral angle tenderness. Urinalysis showed microscopic haematuria 3+ and absence of pyuria. She had a white blood cell count of 13.9 × 10 9 /L with 89% polymorphs and a blood creatinine level of 1.0 mg/dL (91 µmol/L). The alanine transaminase level was 168 U/L, and the lactate dehydrogenase level was 1083 U/L (normal value 87-213 U/L). Both abdominal plain film and ultrasound showed no evidence of hydronephrosis or renal calculi. The following day she developed fever without chills. She was treated empirically as pyelonephritis with ciprofloxacin, which did not alleviate her symptoms. She also complained of palpitation symptoms two days after hospitalization; the electrocardiogram showed atrial fibrillation and no evidence of pulmonary embolism. A contrast-enhanced computed tomography of the abdomen and pelvis (Figure 1) was performed five days after admission because of unresolved fever and symptoms. It demonstrated multiple wedge shaped hypodensities indicative of multifocal infarcts involving the right kidney, with evidence of filling defect (thrombus formation) in the main renal artery causing partial obstruction. The patient was anticoagulated and underwent transthoracic and transesophageal echocardiogram. Grossly enlarged atria secondary to rheumatic mitral stenosis was noted with an estimated mitral valve area of 0.76 cm 2 . Apart from an organized thrombus detected over her left atrial appendage, no vegetations were seen on any heart valves.