Edaravone attenuates hydroxyl radical stress and augmented angiotensin II response in diabetic rats

Saini, Anuj Kumar; Patel, Rohit B.; Sharma, Shyam Sunder; Kumar, H S Arun

doi:10.1016/j.phrs.2006.02.003

Cited by 24 publications

(13 citation statements)

References 38 publications

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“…In contrast to this finding, the angiotensin II-induced contractile response in the normal rat under severe hyperglycemic conditions and in the streptozotocin-induced type 1 diabetic rat has been shown to be enhanced (30,31). This result and our finding suggest that severe hyperglycemia but not moderate hyperglycemia may lead to the upregulation of angiotensin II type 1 receptors.…”

Section: Discussioncontrasting

confidence: 91%

Acute Hyperglycemia and Hyperinsulinemia Enhance Adrenergic Vasoconstriction and Decrease Calcitonin Gene-Related Peptide-Containing Nerve-Mediated Vasodilation in Pithed Rats

et al. 2008

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Section: Discussioncontrasting

confidence: 91%

Acute Hyperglycemia and Hyperinsulinemia Enhance Adrenergic Vasoconstriction and Decrease Calcitonin Gene-Related Peptide-Containing Nerve-Mediated Vasodilation in Pithed Rats

et al. 2008

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“…A reduction in antioxidant activity and an increase in oxidative stress occur early after the diagnosis of type I diabetes mellitus in human patients [85]. Hydroxyl radical stress augments an angiotensin II-induced contractile response in diabetic rat thoracic aorta, and edaravone attenuates hydroxyl radical stress and the augmented angiotensin II-induced contractile response in diabetic rats [86]. Edaravone could be an ideal antioxidant adjuvant in the therapy of diabetic vascular complications.…”

Section: Oxidative Stress and Edaravone Efficacy In Cardiovascularmentioning

confidence: 99%

The Efficacy of Edaravone (Radicut), a Free Radical Scavenger, for Cardiovascular Disease

Kikuchi

Tancharoen

Takeshige

et al. 2013

IJMS

103

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Edaravone was originally developed as a potent free radical scavenger, and has been widely used to treat acute ischemic stroke in Japan since 2001. Free radicals play an important role in the pathogenesis of a variety of diseases, such as cardiovascular diseases and stroke. Therefore, free radicals may be targets for therapeutic intervention in these diseases. Edaravone shows protective effects on ischemic insults and inflammation in the heart, vessel, and brain in experimental studies. As well as scavenging free radicals, edaravone has anti-apoptotic, anti-necrotic, and anti-cytokine effects in cardiovascular diseases and stroke. Edaravone has preventive effects on myocardial injury following ischemia and reperfusion in patients with acute myocardial infarction. Edaravone may represent a new therapeutic intervention for endothelial dysfunction in the setting of atherosclerosis, heart failure, diabetes, or hypertension, because these diseases result from oxidative stress and/or cytokine-induced apoptosis. This review evaluates the potential of edaravone for treatment of cardiovascular disease, and covers clinical and experimental studies conducted between 1984 and 2013. We propose that edaravone, which scavenges free radicals, may offer a novel option for treatment of cardiovascular diseases. However, additional clinical studies are necessary to verify the efficacy of edaravone.

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“…Hydroxyl radicals, which are highly reactive and deleterious ROS, have been found to lead to endothelial dysfunction [40] , and their involvement in mediating augmented Ang II responses is quite possible. The involvement of hydroxyl radicals in the augmented responses to Ang II in diabetic rats [16] has also been reported. Hence we studied the involvement of hydroxyl radical stress in the augmented Ang II-induced vasoconstriction in SHR using edaravone as our tool.…”

Section: Discussionmentioning

confidence: 93%

“…Pharmacology 2007;79: [122][123][124][125][126][127][128] 123 mented responses to Ang II in diabetic rats [16] . No study has been carried out to demonstrate the contributions of hydroxyl radicals in the augmented responses to Ang II in SHR animals.…”

Section: Role Of Hydroxyl Radical Stress In Hypertensionmentioning

confidence: 99%

Hydroxyl Radical Mediates the Augmented Angiotensin II Responses in Thoracic Aorta of Spontaneously Hypertensive Rats

Deshmukh¹,

Patel²,

Patel³

2007

Pharmacology

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Aim: To investigate the role of hydroxyl radical in augmented angiotensin II (Ang II) responses in the thoracic aorta of spontaneously hypertensive rats (SHR). Methods: To elucidate the role of hydroxyl radical, we used edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one) as a tool for our study. The vascular responses to Ang II (10^–10 to 10^–6 mol/l), tert-butyl hydroperoxide (tBHP; 10^–6 to 10^–2 mol/l) and H₂O₂ (10^–6 to 10^–2 mol/l) were constructed in aortic preparations obtained from control (WKY) and SHR in the absence and presence of edaravone. Results: The vascular responses to Ang II, tBHP and H₂O₂ were found to be enhanced in aortic preparations from SHR as compared to control WKY rats. Edaravone selectively attenuated the augmented responses to Ang II but not to tBHP and H₂O₂ suggesting that the ·OH radical is involved in the augmented responses to Ang II. The elevated blood pressure in SHR was restored to a near normal value after 2 weeks of edaravone (10 mg kg^–1 i.p., b.i.d.) treatment. Conclusion: From the results we infer that hydroxyl radical stress augments Ang II responses in the thoracic aorta of SHR and, by attenuating these enhanced vascular responses, edaravone could serve as an adjuvant antioxidant therapy for the vascular complications of hypertension.

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Edaravone attenuates hydroxyl radical stress and augmented angiotensin II response in diabetic rats

Cited by 24 publications

References 38 publications

Acute Hyperglycemia and Hyperinsulinemia Enhance Adrenergic Vasoconstriction and Decrease Calcitonin Gene-Related Peptide-Containing Nerve-Mediated Vasodilation in Pithed Rats

Acute Hyperglycemia and Hyperinsulinemia Enhance Adrenergic Vasoconstriction and Decrease Calcitonin Gene-Related Peptide-Containing Nerve-Mediated Vasodilation in Pithed Rats

The Efficacy of Edaravone (Radicut), a Free Radical Scavenger, for Cardiovascular Disease

Hydroxyl Radical Mediates the Augmented Angiotensin II Responses in Thoracic Aorta of Spontaneously Hypertensive Rats

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