How to construct an appropriate spatial consistent measurement is the key to improving image retrieval performance. To address this problem, this paper introduces a novel image retrieval mechanism based on the family filtration in object region. First, we supply an object region by selecting a rectangle in a query image such that system returns a ranked list of images that contain the same object, retrieved from the corpus based on 100 images, as a result of the first rank. To further improve retrieval performance, we add an efficient spatial consistency stage, which is named family-based spatial consistency filtration, to re-rank the results returned by the first rank. We elaborate the performance of the retrieval system by some experiments on the dataset selected from the key frames of "TREC Video Retrieval Evaluation 2005 (TRECVID2005)". The results of experiments show that the retrieval mechanism proposed by us has vast major effect on the retrieval quality. The paper also verifies the stability of the retrieval mechanism by increasing the number of images from 100 to 2000 and realizes generalized retrieval with the object outside the dataset.