Edelgasreaktionen in der Strahlenchemie

Bünau, Günther von

doi:10.1007/978-3-662-25978-8_2

Cited by 2 publications

(1 citation statement)

References 104 publications

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“…[6] Fluorescence is av ersatile imaging modality for activatable theranosticsd ue to the inherents ensitivity of fluorophores to dye interactions, which enables manipulationo f their photonic properties through controlled supramolecular assemblya nd disassembly. [7] For example, "off/on" activation is commonly achievedu sing dye loadingss ufficientt op romote aggregation-induced self-quenching, [8] which is reversed upon nanocarrier disruption (e.g.,b yc ell uptake and lysosomal degradation). [9,10] The most significant disadvantage of this "off/on" strategy is that it is fundamentally impossible to distinguish fluorescenced ue to intact nanocarrier accumulation from that due to activation.…”

Section: Introductionmentioning

confidence: 99%

Nanostructure‐Dependent Ratiometric NIR Fluorescence Enabled by Ordered Dye Aggregation

2016

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Nanocarriersi ncorporating therapeutic and imaging agentsw ithin as ingle nanostructure are emergingt ools for drug development and treatment planning. Additional information can be provided using activatable fluorescence that dynamically reports nanocarrier disruption and drugr elease. Dual-wavelengtha ctivation encodes au nique fluorescence signal for each nanocarrier state, enabling use of ratiometric imaging to measure the proportion of intact and disrupted nanocarriers within tissues. Here we investigate dualwavelength activation using as ingle dyew hose optical properties are intricately linked to the nanocarrier structure. Naturalb acteriochlorophyll incorporated within ac ompact lipoprotein nanocarrier forms ordered dye aggregates with red-shifted fluorescencee missionf rom 765 nm to 825 nm. We demonstrate that bacteriochlorophyll-ordered aggregation is af easible strategy to distinguish intact and disrupted theranostic nanocarriers by ratiometric fluorescence imaging.

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