Edema de papila y obstrucción de arteria y vena central de la retina como manifestación inicial de una recaída leucémica

Méndez, R. Salazar; Gil, M. Fonollá

doi:10.1016/j.oftal.2013.10.011

Cited by 9 publications

(3 citation statements)

References 5 publications

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“…This entity combines the clinical features of central retinal artery occlusion (CRAO) and central retinal vein occlusion (CRVO), such as ischemic retinal whitening, a cherry-red spot in the macula, retinal hemorrhage, and dilated and/or tortuous retinal veins. Conditions such as systemic lupus erythematosus [1, 2], Behçet's syndrome [3], orbital inflammatory pseudotumor [4], posterior scleritis [5], retrobulbar injection [6], ocular trauma [7], hyperhomocysteinemia [8], and leukemia [9] have been reported to be associated with this disorder. Since only a small number of cases have been reported, the course, clinical manifestations, and visual prognosis have not been well defined.…”

Section: Introductionmentioning

confidence: 99%

Clinical Features of Combined Central Retinal Artery and Vein Occlusion

Wang

Chang

Zhang

et al. 2019

Journal of Ophthalmology

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Purpose To describe the clinical features of combined central retinal artery and vein occlusion (CCRAVO). Methods This retrospective study included 33 admitted patients (33 eyes) who had CCRAVO. Clinical data, such as age, gender, best-corrected visual acuity (BCVA), intraocular pressure (IOP), findings on fundus color photography and fundus fluorescein angiography (FFA), and information about follow-up, were collected and analyzed. Results The age of the patients with CCRAVO ranged from 22 to 78 years, with a mean of 48.8 ± 14.1 years. At presentation, BCVA of the involved eyes ranged from no light perception (NLP) to 20/20. In addition, 45.5% (15/33) of the eyes had BCVA of finger counting (FC) or below, whereas 12.1% (4/33) had BCVA of 20/60 or above. The IOP was lower in the involved eyes than in the fellow eyes (15.0 ± 3.0 mmHg vs. 16.4 ± 2.3 mmHg, p=0.03). Ophthalmoscopic examination showed changes in both central retinal artery occlusion (CRAO) and central retinal vein occlusion (CRVO), including retinal hemorrhage, retinal ischemic whitening, optic disc hyperemia and/or edema, venous dilation and tortuosity, cotton wool spot (CWS), and Roth's spot. FFA showed prolonged arm-to-retina time (ART) and retinal arteriovenous passage time (RAP) (17.1 ± 4.9 s and 12.1 ± 8.8 s, respectively). Capillary nonperfusion (CNP) was seen in 21 eyes (63.6%), and in 14 (42.2%) of these, CNP was larger than 10 disc areas. At 2 to 3 weeks after presentation, BCVA improved in 23 eyes (71.9%) and further deteriorated in 5 eyes (15.6%). Retinal ischemic whitening improved in more than half of the eyes, whereas retinal hemorrhage increased in nearly half of the eyes. Follow-up ranged from 6 to 56 months. Seven patients were lost to follow-up. At final follow-up, six eyes had a visual acuity of 20/60 or greater, but 6 eyes had FC or worse. Four eyes developed neovascularization on follow-up. Conclusion CCRAVO is a sight-threatening entity. Manifestations of CRAO and CRVO can be seen simultaneously in the early stage of disease, and CRVO may play a more important role in the development of CCRAVO.

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Section: Introductionmentioning

confidence: 99%

Clinical Features of Combined Central Retinal Artery and Vein Occlusion

Wang

Chang

Zhang

et al. 2019

Journal of Ophthalmology

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“…Even though CRVO is related with an hypercoagulable state, all the cases described in the literature that associate CRVO with ALL are secondary to an infiltration of leukemic cells. 4–6 All cases show infiltration of the optic disk preceding vessel occlusion.…”

Section: Discussionmentioning

confidence: 99%

“… 3 The association between central retinal vein occlusion and acute lymphoblastic leukemia (ALL) relapse has rarely been described though. 4–6 We hereby report a case of central retinal vein occlusion as the presenting manifestation of relapse in ALL.…”

Section: Introductionmentioning

confidence: 92%