Edema generalizado e circulação hiperdinâmica: um possível caso de beribéri

Minicucci, Marcos F.; Zornoff, Leonardo A. M.; Matsue, Mirna; Inoue, R; Matsubara, Luiz Shiguero; Okoshi, Marina Politi; Okoshi, Katashi; Campana, Álvaro Oscar; Paiva, Sérgio Alberto Rupp de

doi:10.1590/s0066-782x2004001400009

Cited by 4 publications

(1 citation statement)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Com base nos resultados dos exames, somado ao quadro clínico, foi feita a hipótese diagnóstica de beribéri. O paciente apresentou regressão dos sinais e sintomas após tratamento com tiamina(Minicucci et al, 2004).…”

unclassified

Perfil epidemiológico do beribéri notificado de 2006 a 2008 no estado do Maranhão, Brasil e as ações de enfrentamento

Padilha¹

View full text Add to dashboard Cite

Introduction: Beriberi is a disease caused by a deficiency of thiamine (vitamin B1) which, although easily treatable, may lead to death. There had been no register of beriberi outbreaks in Brazil for at least seventy years. Objective: To describe the epidemiological profile of reported beriberi cases in the State of Maranhão. Method: A descriptive retrospective study of 1,207 reported beriberi cases and 40 deaths in the State of Maranhão from 2006 to 2008. The information was obtained from the database of Epidemiological Surveillance and the reporting forms. Results: The cases were distributed in 434 (36.0%) in 2006, 551 (45.6%) in 2007 and 222 (18.4%) in 2008. It affected two thirds of the Regional Health Units and 26.3% of the municipalities located in the Central-Western, Northwestern and Southwestern of the State. The notifications were higher in the months from March to August, peaking in June. The incidence rate in the period was 4.32 / 10,000 inhabitants. Men were more affected (81.9%), with more concentration of cases in the age group 20-40 years (57.0%). Dry beriberi was predominant (84.6%) and the elapsed time between first symptoms and reporting was less than three months in two thirds of cases. Hospitalization occurred for 50.0% of cases in 2006, 30.0% in 2007 and 15.0% in 2008. Alcohol consumption was reported by 53.2% of patients in 2006 and slightly lower proportion in subsequent years, and smoking was reported for about one-third of patients. Main symptoms were loss of strength, numbness and swelling of the legs, difficulty in walking and calf pain. Regarding education it was found that more than half (57.2%) had four or fewer years of study, two thirds (66.2%) performed heavy labor activity and 72.9% had a family income lower than minimum wage. Forty deaths were recorded (3.3% of all reported cases) only in 2006, concentrated in the month of June (61.9%) and distributed in 21 municipalities (9.7%). The mortality rate for the State was 0.45 per 10,000 inhabitants. Almost all the deaths occurred in males (97.5%), and 72.5% aged 20-30 years. For two-thirds of the patients who died, the elapsed time between first symptoms and reporting was less than three months and hospitalization occurred in 42.5%. Alcohol consumption and smoking were higher among those who died, 75.0% and 66.7% respectively. Conclusion: This study stands out for including analysis of all reported beriberi cases in the State of Maranhão. It was found that cases and deaths showed spatial and temporal distribution related to the social reality of the State. The absence of deaths in 2007 and 2008 and reduction of cases in 2008 suggest positive effects of the implemented governmental actions. This descriptive evaluation is important to guide the activities and areas to be prioritized in the planning of actions at the central level (federal, state and municipal), as well as for guiding the practice of primary and specialized healthcare professionals. The results also contribute to the design of other research that may support the study ...

show abstract

unclassified

Perfil epidemiológico do beribéri notificado de 2006 a 2008 no estado do Maranhão, Brasil e as ações de enfrentamento

Padilha¹

View full text Add to dashboard Cite

show abstract

Role of Thiamin in Health and Disease

et al. 2019

Self Cite

View full text Add to dashboard Cite

Thiamin is a hydrosoluble vitamin that plays a role in several biological processes, mainly in glucose metabolism. There are several risk factors for developing thiamin deficiency, such as malnutrition, refeeding syndrome, gastrointestinal surgery, and alcoholism. Recently, the role of thiamin in critically ill patients has gained prominence, and the prevalence of thiamin deficiency was found to be increased in patients with severe burns, major surgery, septic shock, end-stage renal disease, and heart failure. In adults, thiamin deficiency presents as encephalopathy, dry beriberi (with neurological signs and symptoms), or wet beriberi (with cardiovascular signs and symptoms). Thiamin deficiency can be diagnosed clinically, and all clinicians should be aware of this disease, especially in patients with risk factors for thiamin deficiency. Thiamin supplementation should be started as early as possible in patients suspected to have thiamin deficiency. Treatment is safe, inexpensive, simple, and life-saving. Diagnosis is confirmed on a positive response to treatment. (Nutr Clin Pract. 2019;34:558-564)

show abstract

Wet Beriberi Associated with Hikikomori Syndrome

Tanabe¹,

Hiraoka²,

Kataoka³

et al. 2017

J GEN INTERN MED

View full text Add to dashboard Cite

Wet beriberi, characterized by high cardiac output with predominantly right-sided heart failure and lactic acidosis, is a disease caused by thiamine deficiency, and is rarely seen in modern society. However, patients with social withdrawal syndrome, also known as hikikomori syndrome, may be a new population at risk of thiamine deficiency. Hikikomori syndrome, first recognized in Japan, is becoming a worldwide issue. A 39-year-old Japanese patient was brought to our hospital, with a 3-week history of progressive shortness of breath and generalized edema. The patient had right-sided high-output heart failure, lactic acidosis, and Wernicke-Korsakoff syndrome. Because of his history of social isolation, we diagnosed hikikomori syndrome according to the Japanese government's definition, which is as follows: lifestyle centered at home; no interest or willingness to attend school or work; persistence of symptoms beyond 6 months; and exclusion of other psychiatric and developmental disorders. Considering his diagnosis of hikikomori syndrome and social isolation, we suspected malnutrition, particularly thiamine deficiency, and successfully treated him. Clinicians should be aware of the potential risk of thiamine deficiency associated with hikikomori syndrome and initiate thiamine replacement in cases of high-output heart failure associated with lactic acidosis.

show abstract

Edema generalizado e circulação hiperdinâmica: um possível caso de beribéri

Cited by 4 publications

References 6 publications

Perfil epidemiológico do beribéri notificado de 2006 a 2008 no estado do Maranhão, Brasil e as ações de enfrentamento

Perfil epidemiológico do beribéri notificado de 2006 a 2008 no estado do Maranhão, Brasil e as ações de enfrentamento

Role of Thiamin in Health and Disease

Wet Beriberi Associated with Hikikomori Syndrome

Contact Info

Product

Resources

About