The latest cellular technology, known as 5G, is anticipated to significantly improve the way systems in the physical and social environment (PSE) interact with technology. 5G technologies allow for the creation of a wide range of novel automation and applications. Recently, the Internet of Things (IoT), virtual and augmented reality (VAR), telemedicine, and autonomous vehicles have increased the growth of applications in the PSEs and can further benefit from 5G’s fast data transfer speeds (ranging from 1 to 10 Gbps) and low latency. The introduction of 5G may cause a paradigm shift in the operations of some industries, offer new economic opportunities, and impact our daily lives and relationships with the PSE. In this chapter, we examine how 5G revolutionize transport, the environment, and health. The chapter focuses on recent technologies related to virtual and augmented reality, autonomous vehicles, telemedicine, and edge computing among others.