Supply chain management and information technology are tightly coupled. Implementation of supply chain strategies would be very difficult without the support of information technology. At the same time, many developments in information technology have arisen from requirements set by enterprises seeking collaboration with their partners in the supply chain environment. For instance, the development of web services has been driven by a need for flexibility and more open information systems interfaces to support reconfigurability.This chapter describes the information technologies used to support supply chain configuration, both from the decision-making and decision-implementation perspectives. Information technologies include hardware, communications, and software. Here, the focus is on software. Hardware and communications are described only at the conceptual level in relation to the general architectures of information technology solutions in the supply chain management framework.The chapter starts with outlining major aspects of information technology usage in supply chain management, and supply chain configuration in particular. The classification of applications used is provided. Section 10.3 describes applications used for decision-making purposes. Section 10.4 discusses the supply chain management information system, with emphasis on the use of flexible, service-oriented architecture. A prototype of the supply chain configuration decision-making system is described in Sect. 10.5.